Advances in fish cytokine biology give clues to the evolution of a complex network

Steven Bird, Jun Zou, Christopher John Secombes

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Complex immune systems require complex regulatory mechanisms. Whilst the control of innate and inflammatory responses is likely to be ancient in origin, and potentially ubiquitous in the animal kingdom, clearly the evolution of an adaptive immune system in vertebrates is likely to coincide with new regulatory mechanisms and molecules. Key amongst these is the cytokine network, well characterised in mammals and becoming increasingly well characterised in fish and birds. This article will review our current understanding of which components of this network are crucial for adaptive immunity and evolved early, being present from fish to mammals. It will also consider which components of this network potentially evolved later (after the fish-tetrapod divergence) leading to unique cytokine genes in particular vertebrate groups.

Original languageEnglish
Pages (from-to)3051-3069
Number of pages19
JournalCurrent Pharmaceutical Design
Volume12
Issue number24
DOIs
Publication statusPublished - 1 Aug 2006

Keywords

  • teleost
  • T-helper-1 (Th1)
  • T-helper-2 (Th2)
  • cytokine evolution
  • cell-mediated immunity
  • humoral immunity
  • xenopus
  • growth-factor-BETA
  • tumor-necrosis-factor
  • trout oncorhynchus-mykiss
  • human B-cells
  • chicken interferon-GAMMA
  • T-helper-cell
  • colony-stimulating factor
  • major histocompatability complex
  • interleukin-13 receptor ALPHA-2
  • nuclear-localization sequence

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Advances in fish cytokine biology give clues to the evolution of a complex network. / Bird, Steven; Zou, Jun; Secombes, Christopher John.

In: Current Pharmaceutical Design, Vol. 12, No. 24, 01.08.2006, p. 3051-3069.

Research output: Contribution to journalReview article

@article{1ccb740af583460dbe234317d6953446,
title = "Advances in fish cytokine biology give clues to the evolution of a complex network",
abstract = "Complex immune systems require complex regulatory mechanisms. Whilst the control of innate and inflammatory responses is likely to be ancient in origin, and potentially ubiquitous in the animal kingdom, clearly the evolution of an adaptive immune system in vertebrates is likely to coincide with new regulatory mechanisms and molecules. Key amongst these is the cytokine network, well characterised in mammals and becoming increasingly well characterised in fish and birds. This article will review our current understanding of which components of this network are crucial for adaptive immunity and evolved early, being present from fish to mammals. It will also consider which components of this network potentially evolved later (after the fish-tetrapod divergence) leading to unique cytokine genes in particular vertebrate groups.",
keywords = "teleost, T-helper-1 (Th1), T-helper-2 (Th2), cytokine evolution, cell-mediated immunity, humoral immunity, xenopus, growth-factor-BETA, tumor-necrosis-factor, trout oncorhynchus-mykiss, human B-cells, chicken interferon-GAMMA, T-helper-cell, colony-stimulating factor, major histocompatability complex, interleukin-13 receptor ALPHA-2, nuclear-localization sequence",
author = "Steven Bird and Jun Zou and Secombes, {Christopher John}",
year = "2006",
month = "8",
day = "1",
doi = "10.2174/138161206777947434",
language = "English",
volume = "12",
pages = "3051--3069",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "24",

}

TY - JOUR

T1 - Advances in fish cytokine biology give clues to the evolution of a complex network

AU - Bird, Steven

AU - Zou, Jun

AU - Secombes, Christopher John

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Complex immune systems require complex regulatory mechanisms. Whilst the control of innate and inflammatory responses is likely to be ancient in origin, and potentially ubiquitous in the animal kingdom, clearly the evolution of an adaptive immune system in vertebrates is likely to coincide with new regulatory mechanisms and molecules. Key amongst these is the cytokine network, well characterised in mammals and becoming increasingly well characterised in fish and birds. This article will review our current understanding of which components of this network are crucial for adaptive immunity and evolved early, being present from fish to mammals. It will also consider which components of this network potentially evolved later (after the fish-tetrapod divergence) leading to unique cytokine genes in particular vertebrate groups.

AB - Complex immune systems require complex regulatory mechanisms. Whilst the control of innate and inflammatory responses is likely to be ancient in origin, and potentially ubiquitous in the animal kingdom, clearly the evolution of an adaptive immune system in vertebrates is likely to coincide with new regulatory mechanisms and molecules. Key amongst these is the cytokine network, well characterised in mammals and becoming increasingly well characterised in fish and birds. This article will review our current understanding of which components of this network are crucial for adaptive immunity and evolved early, being present from fish to mammals. It will also consider which components of this network potentially evolved later (after the fish-tetrapod divergence) leading to unique cytokine genes in particular vertebrate groups.

KW - teleost

KW - T-helper-1 (Th1)

KW - T-helper-2 (Th2)

KW - cytokine evolution

KW - cell-mediated immunity

KW - humoral immunity

KW - xenopus

KW - growth-factor-BETA

KW - tumor-necrosis-factor

KW - trout oncorhynchus-mykiss

KW - human B-cells

KW - chicken interferon-GAMMA

KW - T-helper-cell

KW - colony-stimulating factor

KW - major histocompatability complex

KW - interleukin-13 receptor ALPHA-2

KW - nuclear-localization sequence

UR - http://www.scopus.com/inward/record.url?scp=33747152222&partnerID=8YFLogxK

U2 - 10.2174/138161206777947434

DO - 10.2174/138161206777947434

M3 - Review article

VL - 12

SP - 3051

EP - 3069

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 24

ER -