Advancing human health risk assessment

Anna Lanzoni (Corresponding Author), Anna F. Castoldi, George E.N. Kass, Andrea Terron, Guilhem De Seze, Anna Bal-Price, Frédéric Y. Bois, K. Barry Delclos, Daniel R. Doerge, Ellen Fritsche, Thorhallur Halldorsson, Marike Kolossa-Gehring, Susanne Hougaard Bennekou, Frits Koning, Alfonso Lampen, Marcel Leist, Ellen Mantus, Christophe Rousselle, Michael Siegrist, Pablo SteinbergAngelika Tritscher, Bob Van de Water, Paolo Vineis, Nigel Walker, Heather Wallace, Maurice Whelan, Maged Younes

Research output: Contribution to journalArticle

7 Citations (Scopus)
5 Downloads (Pure)

Abstract

The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).
Original languageEnglish
Article numbere170712
Number of pages21
JournalEFSA Journal
Volume17
Issue numberS1
Early online date8 Jul 2019
DOIs
Publication statusPublished - Jul 2019
EventEFSA's third Scientific Conference ‘Science, Food and Society’ - Parma, Italy
Duration: 18 Sep 201821 Sep 2018

Keywords

  • alternative methods
  • exposure
  • epidemiology
  • food safety
  • mechanistic studies
  • risk assessment

Fingerprint Dive into the research topics of 'Advancing human health risk assessment'. Together they form a unique fingerprint.

Cite this