Age-, and gender-specific incidence of vascular parkinsonism, progressive supranuclear palsy, and parkinsonian-type multiple system atrophy in North East Scotland: The PINE study

Robert Caslake, Kate Taylor, Neil William Scott, Clare Harris, Joanna Gordon, Katie Wilde, Alison Murray, Carl Counsell

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Abstract

Introduction
There have been few incidence studies of vascular parkinsonism (VP), progressive supranuclear palsy (PSP), and parkinsonian-type multiple system atrophy (MSA-P). We measured the age-, gender- and socioeconomic-specific incidence rates for these conditions in north-east Scotland.

Methods
Incident non drug-induced parkinsonian patients were identified prospectively over three years by several overlapping methods from a baseline primary care population of 311,357. Parkinsonism was diagnosed if patients had two or more cardinal motor signs. Patients had yearly follow-up to improve diagnostic accuracy.

Incidence rates using the diagnosis by established research criteria at latest follow-up were calculated for each condition by age, gender, and socioeconomic status.

Results
Of 377 patients identified at baseline with possible or probable parkinsonism, 363 were confirmed as incident patients after median follow-up of 26 months (mean age 74.8 years, SD 9.8; 61% men). The crude annual incidence was 3.2 per 100,000 (95% confidence interval (CI) 2.2–4.3) for VP, 1.7 per 100,000 (95% CI 1.0–2.4) for PSP, and 1.4 per 100,000 (95% CI 0.8–2.1) for MSA-P. VP and MSA-P were more common in men (age-adjusted male to female ratios 2.58 (95% CI 1.65–3.83) and 8.65 (95% CI 4.73–14.5) respectively). Incidence did not vary with socioeconomic status.

Discussion
This is the first community-based, prospective study to report the incidence of vascular parkinsonism and the third to report the incidence of PSP and MSA-P. Further follow-up and comparison with similar studies in different populations will yield valuable prognostic and aetiological information on these conditions.
Original languageEnglish
Pages (from-to)834-839
Number of pages6
JournalParkinsonism & Related Disorders
Volume20
Issue number8
Early online date30 Apr 2014
DOIs
Publication statusPublished - Aug 2014

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Progressive Supranuclear Palsy
Multiple System Atrophy
Parkinsonian Disorders
Scotland
Blood Vessels
Confidence Intervals
Incidence
Social Class
Population
Primary Health Care
Cohort Studies
Prospective Studies
Research
Pharmaceutical Preparations

Keywords

  • parkinsonism
  • vascular parkinsonism
  • multiple system atrophy
  • progressive supranuclear palsy
  • incidence

Cite this

@article{09597341f92847a98cbad3a83536188e,
title = "Age-, and gender-specific incidence of vascular parkinsonism, progressive supranuclear palsy, and parkinsonian-type multiple system atrophy in North East Scotland: The PINE study",
abstract = "IntroductionThere have been few incidence studies of vascular parkinsonism (VP), progressive supranuclear palsy (PSP), and parkinsonian-type multiple system atrophy (MSA-P). We measured the age-, gender- and socioeconomic-specific incidence rates for these conditions in north-east Scotland.MethodsIncident non drug-induced parkinsonian patients were identified prospectively over three years by several overlapping methods from a baseline primary care population of 311,357. Parkinsonism was diagnosed if patients had two or more cardinal motor signs. Patients had yearly follow-up to improve diagnostic accuracy.Incidence rates using the diagnosis by established research criteria at latest follow-up were calculated for each condition by age, gender, and socioeconomic status.ResultsOf 377 patients identified at baseline with possible or probable parkinsonism, 363 were confirmed as incident patients after median follow-up of 26 months (mean age 74.8 years, SD 9.8; 61{\%} men). The crude annual incidence was 3.2 per 100,000 (95{\%} confidence interval (CI) 2.2–4.3) for VP, 1.7 per 100,000 (95{\%} CI 1.0–2.4) for PSP, and 1.4 per 100,000 (95{\%} CI 0.8–2.1) for MSA-P. VP and MSA-P were more common in men (age-adjusted male to female ratios 2.58 (95{\%} CI 1.65–3.83) and 8.65 (95{\%} CI 4.73–14.5) respectively). Incidence did not vary with socioeconomic status.DiscussionThis is the first community-based, prospective study to report the incidence of vascular parkinsonism and the third to report the incidence of PSP and MSA-P. Further follow-up and comparison with similar studies in different populations will yield valuable prognostic and aetiological information on these conditions.",
keywords = "parkinsonism, vascular parkinsonism, multiple system atrophy , progressive supranuclear palsy, incidence",
author = "Robert Caslake and Kate Taylor and Scott, {Neil William} and Clare Harris and Joanna Gordon and Katie Wilde and Alison Murray and Carl Counsell",
note = "Copyright {\circledC} 2014 Elsevier Ltd. All rights reserved. Acknowledgments We thank our funders Parkinson's UK (G-0502), Doris Hillier BMA Award, the BUPA Foundation, SPRING, NHS Grampian Endowments), Susan Kilpatrick for secretarial support, and all the patients and general practices that took part.",
year = "2014",
month = "8",
doi = "10.1016/j.parkreldis.2014.04.013",
language = "English",
volume = "20",
pages = "834--839",
journal = "Parkinsonism & Related Disorders",
issn = "1353-8020",
publisher = "Elsevier BV",
number = "8",

}

TY - JOUR

T1 - Age-, and gender-specific incidence of vascular parkinsonism, progressive supranuclear palsy, and parkinsonian-type multiple system atrophy in North East Scotland

T2 - The PINE study

AU - Caslake, Robert

AU - Taylor, Kate

AU - Scott, Neil William

AU - Harris, Clare

AU - Gordon, Joanna

AU - Wilde, Katie

AU - Murray, Alison

AU - Counsell, Carl

N1 - Copyright © 2014 Elsevier Ltd. All rights reserved. Acknowledgments We thank our funders Parkinson's UK (G-0502), Doris Hillier BMA Award, the BUPA Foundation, SPRING, NHS Grampian Endowments), Susan Kilpatrick for secretarial support, and all the patients and general practices that took part.

PY - 2014/8

Y1 - 2014/8

N2 - IntroductionThere have been few incidence studies of vascular parkinsonism (VP), progressive supranuclear palsy (PSP), and parkinsonian-type multiple system atrophy (MSA-P). We measured the age-, gender- and socioeconomic-specific incidence rates for these conditions in north-east Scotland.MethodsIncident non drug-induced parkinsonian patients were identified prospectively over three years by several overlapping methods from a baseline primary care population of 311,357. Parkinsonism was diagnosed if patients had two or more cardinal motor signs. Patients had yearly follow-up to improve diagnostic accuracy.Incidence rates using the diagnosis by established research criteria at latest follow-up were calculated for each condition by age, gender, and socioeconomic status.ResultsOf 377 patients identified at baseline with possible or probable parkinsonism, 363 were confirmed as incident patients after median follow-up of 26 months (mean age 74.8 years, SD 9.8; 61% men). The crude annual incidence was 3.2 per 100,000 (95% confidence interval (CI) 2.2–4.3) for VP, 1.7 per 100,000 (95% CI 1.0–2.4) for PSP, and 1.4 per 100,000 (95% CI 0.8–2.1) for MSA-P. VP and MSA-P were more common in men (age-adjusted male to female ratios 2.58 (95% CI 1.65–3.83) and 8.65 (95% CI 4.73–14.5) respectively). Incidence did not vary with socioeconomic status.DiscussionThis is the first community-based, prospective study to report the incidence of vascular parkinsonism and the third to report the incidence of PSP and MSA-P. Further follow-up and comparison with similar studies in different populations will yield valuable prognostic and aetiological information on these conditions.

AB - IntroductionThere have been few incidence studies of vascular parkinsonism (VP), progressive supranuclear palsy (PSP), and parkinsonian-type multiple system atrophy (MSA-P). We measured the age-, gender- and socioeconomic-specific incidence rates for these conditions in north-east Scotland.MethodsIncident non drug-induced parkinsonian patients were identified prospectively over three years by several overlapping methods from a baseline primary care population of 311,357. Parkinsonism was diagnosed if patients had two or more cardinal motor signs. Patients had yearly follow-up to improve diagnostic accuracy.Incidence rates using the diagnosis by established research criteria at latest follow-up were calculated for each condition by age, gender, and socioeconomic status.ResultsOf 377 patients identified at baseline with possible or probable parkinsonism, 363 were confirmed as incident patients after median follow-up of 26 months (mean age 74.8 years, SD 9.8; 61% men). The crude annual incidence was 3.2 per 100,000 (95% confidence interval (CI) 2.2–4.3) for VP, 1.7 per 100,000 (95% CI 1.0–2.4) for PSP, and 1.4 per 100,000 (95% CI 0.8–2.1) for MSA-P. VP and MSA-P were more common in men (age-adjusted male to female ratios 2.58 (95% CI 1.65–3.83) and 8.65 (95% CI 4.73–14.5) respectively). Incidence did not vary with socioeconomic status.DiscussionThis is the first community-based, prospective study to report the incidence of vascular parkinsonism and the third to report the incidence of PSP and MSA-P. Further follow-up and comparison with similar studies in different populations will yield valuable prognostic and aetiological information on these conditions.

KW - parkinsonism

KW - vascular parkinsonism

KW - multiple system atrophy

KW - progressive supranuclear palsy

KW - incidence

U2 - 10.1016/j.parkreldis.2014.04.013

DO - 10.1016/j.parkreldis.2014.04.013

M3 - Article

VL - 20

SP - 834

EP - 839

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

SN - 1353-8020

IS - 8

ER -