Age and the architecture of oral mucosa

Rasha Abu Eid, Faleh Sawair, Gabriel Landini, Takashi Saku

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Age changes affect the oral mucosa (the protective lining of the oral cavity), but few of these have been studied objectively. The aim of this study was to quantitatively analyse a number of morphometric parameters of the ageing oral mucosa. The fractal dimension of the epithelial connective tissue interface (ECTI) was estimated in 42 samples of normal buccal mucosa to correlate any changes in their irregularity to the age of the individuals. Morphometric parameters extracted from theoretical cell areas computed programatically were also analysed. Results showed no significant change in ECTI complexity associated with age; however, there was indication that epithelial cells tended to become larger and flatter with age. Interestingly, while some parameters did not show significant differences case wise, cluster analysis showed that the data clustered the cases into three main age groups: one representing the first two decades of life, another group represents adult life (21-50 years) and the last group representing the ageing population (50-90 years).

Original languageEnglish
Pages (from-to)651-8
Number of pages8
Issue number3
Early online date11 May 2011
Publication statusPublished - Jun 2012


  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Child
  • Child, Preschool
  • Epithelial Cells
  • Humans
  • Image Processing, Computer-Assisted
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Mouth Mucosa
  • Young Adult
  • Comparative Study
  • Journal Article
  • Oral mucosa
  • Fractal
  • Tissue architecture
  • Morphology


Dive into the research topics of 'Age and the architecture of oral mucosa'. Together they form a unique fingerprint.

Cite this