Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations

Elizabeth A Miles, Dinka Rees, Tapati Banerjee, Roberta Cazzola, Sian Lewis, Richard Wood, Rachael Oates, Anna Tallant, Benvenuto Cestaro, Parveen Yaqoob, Klaus W J Wahle, Philip C Calder

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these.

METHODS AND RESULTS: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for.

CONCLUSIONS: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.

Original languageEnglish
Pages (from-to)298-305
Number of pages8
JournalAtherosclerosis
Volume196
Issue number1
DOIs
Publication statusPublished - Jan 2008

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Chemokine CCL21
Blood Pressure
Lipids
Interleukin-6
Selectins
Interleukin-18
Adiponectin
Adipokines
Chemokines
LDL Cholesterol
HDL Cholesterol
Healthy Volunteers
Triglycerides
Cholesterol
Cytokines
Inflammation

Keywords

  • Adiponectin
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Blood Pressure
  • Body Mass Index
  • Cell Adhesion Molecules
  • Cholesterol
  • Cross-Sectional Studies
  • Cytokines
  • Humans
  • Inflammation
  • Male
  • Middle Aged
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations. / Miles, Elizabeth A; Rees, Dinka; Banerjee, Tapati; Cazzola, Roberta; Lewis, Sian; Wood, Richard; Oates, Rachael; Tallant, Anna; Cestaro, Benvenuto; Yaqoob, Parveen; Wahle, Klaus W J; Calder, Philip C.

In: Atherosclerosis, Vol. 196, No. 1, 01.2008, p. 298-305.

Research output: Contribution to journalArticle

Miles, EA, Rees, D, Banerjee, T, Cazzola, R, Lewis, S, Wood, R, Oates, R, Tallant, A, Cestaro, B, Yaqoob, P, Wahle, KWJ & Calder, PC 2008, 'Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations', Atherosclerosis, vol. 196, no. 1, pp. 298-305. https://doi.org/10.1016/j.atherosclerosis.2006.11.002
Miles, Elizabeth A ; Rees, Dinka ; Banerjee, Tapati ; Cazzola, Roberta ; Lewis, Sian ; Wood, Richard ; Oates, Rachael ; Tallant, Anna ; Cestaro, Benvenuto ; Yaqoob, Parveen ; Wahle, Klaus W J ; Calder, Philip C. / Age-related increases in circulating inflammatory markers in men are independent of BMI, blood pressure and blood lipid concentrations. In: Atherosclerosis. 2008 ; Vol. 196, No. 1. pp. 298-305.
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AU - Miles, Elizabeth A

AU - Rees, Dinka

AU - Banerjee, Tapati

AU - Cazzola, Roberta

AU - Lewis, Sian

AU - Wood, Richard

AU - Oates, Rachael

AU - Tallant, Anna

AU - Cestaro, Benvenuto

AU - Yaqoob, Parveen

AU - Wahle, Klaus W J

AU - Calder, Philip C

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N2 - OBJECTIVE: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these.METHODS AND RESULTS: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for.CONCLUSIONS: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.

AB - OBJECTIVE: To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these.METHODS AND RESULTS: Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines (adiponectin) were measured in the plasma of healthy male subjects aged 18-84 years (n=162). These were related to known cardiovascular risk factors (age, BMI, systolic and diastolic blood pressure, plasma total cholesterol, LDL cholesterol, HDL cholesterol and triacylglycerol concentrations) in order to identify significant associations. Plasma concentrations of sVCAM-1, sE-selectin, IL-6, IL-18, MCP-1, 6Ckine, IP-10 and adiponectin, but not sICAM-1, were significantly positively correlated with age, as well as with several other cardiovascular risk factors. The correlations with other risk factors disappeared when age was controlled for. In contrast, the correlations with age remained significant for sVCAM-1, IL-6, MCP-1, 6Ckine and IP-10 when other cardiovascular risk factors were controlled for.CONCLUSIONS: Plasma concentrations of some inflammatory markers (sVCAM-1, IL-6, MCP-1, 6Ckine, IP-10) are positively correlated with age, independent of other cardiovascular risk factors. This suggests that age-related inflammation may not be driven by recognised risk factors.

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KW - Aged, 80 and over

KW - Aging

KW - Blood Pressure

KW - Body Mass Index

KW - Cell Adhesion Molecules

KW - Cholesterol

KW - Cross-Sectional Studies

KW - Cytokines

KW - Humans

KW - Inflammation

KW - Male

KW - Middle Aged

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.atherosclerosis.2006.11.002

DO - 10.1016/j.atherosclerosis.2006.11.002

M3 - Article

VL - 196

SP - 298

EP - 305

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 1

ER -