Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood

Louisa Owens, Ingrid A. Laing, Guicheng Zhang, Steve Turner, Peter N. Le Souëf

Research output: Contribution to journalArticle

4 Citations (Scopus)
4 Downloads (Pure)

Abstract

Introduction:
Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period.
Methods:
In this longitudinal study, 253 individuals were recruited antenatally. Lung function and allergy testing occurred at 1, 6, 12 months, 6, 11, 18 and 24 years of age. The relationship between lung function at 1 month (V’maxFRC) and spirometry variables at each follow-up was evaluated. Early life predictors of spirometry were assessed longitudinally using linear mixed models.
Results:
V’maxFRC correlated positively with FEF25-75% at every assessment from 6 to 24 years and FEV1/FVC at 11 and 24 years and inversely with airway responsiveness at 6 and 18 years. Maternal asthma and smoking in pregnancy were associated with lower FEV1 from 6 to 24 years (-99ml, p=0.03; -77ml, p=0.045 respectively). Lower V’maxFRC at 1 month was associated with asthma and wheeze through to 24 years.
Conclusion:
Lung airflow measurements track from birth into early adulthood, suggesting a
permanent and stable airway framework is laid down in the antenatal period. Lower infant airway function is associated with respiratory symptoms into adulthood, indicating the link is clinically important. Antenatal and early life exposures must be addressed in order to maximise airway growth and reduce lifelong respiratory compromise.
Original languageEnglish
Pages (from-to)1082-1088
Number of pages7
JournalPediatric Pulmonology
Volume53
Issue number8
Early online date27 May 2018
DOIs
Publication statusPublished - 1 Aug 2018

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Pulmonary Ventilation
Lung
Spirometry
Asthma
Growth
Longitudinal Studies
Linear Models
Hypersensitivity
Smoking
Mothers
Parturition
Pregnancy

Keywords

  • infant lung function
  • longitudinal birth cohort
  • spirometry
  • asthma

Cite this

Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood. / Owens, Louisa; Laing, Ingrid A.; Zhang, Guicheng; Turner, Steve; Le Souëf, Peter N.

In: Pediatric Pulmonology, Vol. 53, No. 8, 01.08.2018, p. 1082-1088.

Research output: Contribution to journalArticle

Owens, Louisa ; Laing, Ingrid A. ; Zhang, Guicheng ; Turner, Steve ; Le Souëf, Peter N. / Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood. In: Pediatric Pulmonology. 2018 ; Vol. 53, No. 8. pp. 1082-1088.
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title = "Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood",
abstract = "Introduction: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period.Methods:In this longitudinal study, 253 individuals were recruited antenatally. Lung function and allergy testing occurred at 1, 6, 12 months, 6, 11, 18 and 24 years of age. The relationship between lung function at 1 month (V’maxFRC) and spirometry variables at each follow-up was evaluated. Early life predictors of spirometry were assessed longitudinally using linear mixed models.Results: V’maxFRC correlated positively with FEF25-75{\%} at every assessment from 6 to 24 years and FEV1/FVC at 11 and 24 years and inversely with airway responsiveness at 6 and 18 years. Maternal asthma and smoking in pregnancy were associated with lower FEV1 from 6 to 24 years (-99ml, p=0.03; -77ml, p=0.045 respectively). Lower V’maxFRC at 1 month was associated with asthma and wheeze through to 24 years. Conclusion:Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period. Lower infant airway function is associated with respiratory symptoms into adulthood, indicating the link is clinically important. Antenatal and early life exposures must be addressed in order to maximise airway growth and reduce lifelong respiratory compromise.",
keywords = "infant lung function, longitudinal birth cohort, spirometry, asthma",
author = "Louisa Owens and Laing, {Ingrid A.} and Guicheng Zhang and Steve Turner and {Le Sou{\"e}f}, {Peter N.}",
note = "Funding information Princess Margaret Hospital Foundation, Grant number: 9383; National Health and Medical Research Council, Grant number: APP1031635; University of Western Australia PhD scholarship; Asthma Foundation of Western Australia PhD top-up scholarship.",
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AU - Turner, Steve

AU - Le Souëf, Peter N.

N1 - Funding information Princess Margaret Hospital Foundation, Grant number: 9383; National Health and Medical Research Council, Grant number: APP1031635; University of Western Australia PhD scholarship; Asthma Foundation of Western Australia PhD top-up scholarship.

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N2 - Introduction: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period.Methods:In this longitudinal study, 253 individuals were recruited antenatally. Lung function and allergy testing occurred at 1, 6, 12 months, 6, 11, 18 and 24 years of age. The relationship between lung function at 1 month (V’maxFRC) and spirometry variables at each follow-up was evaluated. Early life predictors of spirometry were assessed longitudinally using linear mixed models.Results: V’maxFRC correlated positively with FEF25-75% at every assessment from 6 to 24 years and FEV1/FVC at 11 and 24 years and inversely with airway responsiveness at 6 and 18 years. Maternal asthma and smoking in pregnancy were associated with lower FEV1 from 6 to 24 years (-99ml, p=0.03; -77ml, p=0.045 respectively). Lower V’maxFRC at 1 month was associated with asthma and wheeze through to 24 years. Conclusion:Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period. Lower infant airway function is associated with respiratory symptoms into adulthood, indicating the link is clinically important. Antenatal and early life exposures must be addressed in order to maximise airway growth and reduce lifelong respiratory compromise.

AB - Introduction: Increasing evidence suggests that poor lung function in adulthood is determined very early in life. Our study aims were: (1) identify factors associated with early infant lung function; (2) quantify the link between early infant lung function and early adult lung function; (3) identify environmental and inherited factors which predict lung function throughout the post-natal growth period.Methods:In this longitudinal study, 253 individuals were recruited antenatally. Lung function and allergy testing occurred at 1, 6, 12 months, 6, 11, 18 and 24 years of age. The relationship between lung function at 1 month (V’maxFRC) and spirometry variables at each follow-up was evaluated. Early life predictors of spirometry were assessed longitudinally using linear mixed models.Results: V’maxFRC correlated positively with FEF25-75% at every assessment from 6 to 24 years and FEV1/FVC at 11 and 24 years and inversely with airway responsiveness at 6 and 18 years. Maternal asthma and smoking in pregnancy were associated with lower FEV1 from 6 to 24 years (-99ml, p=0.03; -77ml, p=0.045 respectively). Lower V’maxFRC at 1 month was associated with asthma and wheeze through to 24 years. Conclusion:Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period. Lower infant airway function is associated with respiratory symptoms into adulthood, indicating the link is clinically important. Antenatal and early life exposures must be addressed in order to maximise airway growth and reduce lifelong respiratory compromise.

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