Akinesia becoming dyskinesia following exercise: prevalence and relationship to clinical outcome

Graham Scott Hillis, J. K. Oh, D. W. Mahoney, M. McCully, P. A. Pellikka

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    OBJECTIVES The aim of this study was to determine the prevalence and prognostic implications of dyskinesia developing after exercise.

    BACKGROUND The prevalence and prognostic implications of new-onset dyskinesia with exercise testing have not been previously described.

    METHODS We considered 1,005 consecutive patients who underwent exercise echocardiography and had akinetic segments at rest. Patients were divided according to the presence or absence of exercise-induced dyskinesia. Baseline clinical and echocardiographic parameters were compared, and patients were followed up for a median of 2.7 years.

    RESULTS One hundred four (10%) patients developed dyskinesia after exercise. Compared to patients with segments that remained akinetic, these patients were more likely to have electrocardiographic (ECG) evidence of prior myocardial infarction and, during exercise, had a less pronounced rise in systolic blood pressure and more often had ECG evidence of ischemia. Their resting left ventricular (LV) ejection fraction was worse and improved little after exercise. However, all-cause mortality and the incidence of major adverse cardiac events were similar in the two groups, even after correction for age, gender, and resting LV function (hazard ratio for major adverse cardiac events = 1.36, 95% confidence interval [Cl] 0.82 to 2.26, p = 0.23; hazard ratio for total mortality = 1.20, 95% CI 0.75 to 1.94, p = 0.45).

    CONCLUSIONS One in 10 patients with akinetic myocardium at rest will develop dyskinesia after exercise. This is associated with poorer LV function at rest and little improvement in systolic function after exercise. However, this response has no impact on prognosis. (C) 2004 by the American College of Cardiology Foundation.

    Original languageEnglish
    Pages (from-to)599-605
    Number of pages6
    JournalJournal of the American College of Cardiology
    Volume43
    DOIs
    Publication statusPublished - 2004

    Keywords

    • DOBUTAMINE STRESS ECHOCARDIOGRAPHY
    • CORONARY-ARTERY-DISEASE
    • MYOCARDIAL-ISCHEMIA
    • PROGNOSTIC VALUE

    Cite this

    Akinesia becoming dyskinesia following exercise: prevalence and relationship to clinical outcome. / Hillis, Graham Scott; Oh, J. K.; Mahoney, D. W.; McCully, M.; Pellikka, P. A.

    In: Journal of the American College of Cardiology, Vol. 43, 2004, p. 599-605.

    Research output: Contribution to journalArticle

    Hillis, Graham Scott ; Oh, J. K. ; Mahoney, D. W. ; McCully, M. ; Pellikka, P. A. / Akinesia becoming dyskinesia following exercise: prevalence and relationship to clinical outcome. In: Journal of the American College of Cardiology. 2004 ; Vol. 43. pp. 599-605.
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    abstract = "OBJECTIVES The aim of this study was to determine the prevalence and prognostic implications of dyskinesia developing after exercise.BACKGROUND The prevalence and prognostic implications of new-onset dyskinesia with exercise testing have not been previously described.METHODS We considered 1,005 consecutive patients who underwent exercise echocardiography and had akinetic segments at rest. Patients were divided according to the presence or absence of exercise-induced dyskinesia. Baseline clinical and echocardiographic parameters were compared, and patients were followed up for a median of 2.7 years.RESULTS One hundred four (10{\%}) patients developed dyskinesia after exercise. Compared to patients with segments that remained akinetic, these patients were more likely to have electrocardiographic (ECG) evidence of prior myocardial infarction and, during exercise, had a less pronounced rise in systolic blood pressure and more often had ECG evidence of ischemia. Their resting left ventricular (LV) ejection fraction was worse and improved little after exercise. However, all-cause mortality and the incidence of major adverse cardiac events were similar in the two groups, even after correction for age, gender, and resting LV function (hazard ratio for major adverse cardiac events = 1.36, 95{\%} confidence interval [Cl] 0.82 to 2.26, p = 0.23; hazard ratio for total mortality = 1.20, 95{\%} CI 0.75 to 1.94, p = 0.45).CONCLUSIONS One in 10 patients with akinetic myocardium at rest will develop dyskinesia after exercise. This is associated with poorer LV function at rest and little improvement in systolic function after exercise. However, this response has no impact on prognosis. (C) 2004 by the American College of Cardiology Foundation.",
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    doi = "10.1016/j.jacc.2003.08.053",
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    T1 - Akinesia becoming dyskinesia following exercise: prevalence and relationship to clinical outcome

    AU - Hillis, Graham Scott

    AU - Oh, J. K.

    AU - Mahoney, D. W.

    AU - McCully, M.

    AU - Pellikka, P. A.

    PY - 2004

    Y1 - 2004

    N2 - OBJECTIVES The aim of this study was to determine the prevalence and prognostic implications of dyskinesia developing after exercise.BACKGROUND The prevalence and prognostic implications of new-onset dyskinesia with exercise testing have not been previously described.METHODS We considered 1,005 consecutive patients who underwent exercise echocardiography and had akinetic segments at rest. Patients were divided according to the presence or absence of exercise-induced dyskinesia. Baseline clinical and echocardiographic parameters were compared, and patients were followed up for a median of 2.7 years.RESULTS One hundred four (10%) patients developed dyskinesia after exercise. Compared to patients with segments that remained akinetic, these patients were more likely to have electrocardiographic (ECG) evidence of prior myocardial infarction and, during exercise, had a less pronounced rise in systolic blood pressure and more often had ECG evidence of ischemia. Their resting left ventricular (LV) ejection fraction was worse and improved little after exercise. However, all-cause mortality and the incidence of major adverse cardiac events were similar in the two groups, even after correction for age, gender, and resting LV function (hazard ratio for major adverse cardiac events = 1.36, 95% confidence interval [Cl] 0.82 to 2.26, p = 0.23; hazard ratio for total mortality = 1.20, 95% CI 0.75 to 1.94, p = 0.45).CONCLUSIONS One in 10 patients with akinetic myocardium at rest will develop dyskinesia after exercise. This is associated with poorer LV function at rest and little improvement in systolic function after exercise. However, this response has no impact on prognosis. (C) 2004 by the American College of Cardiology Foundation.

    AB - OBJECTIVES The aim of this study was to determine the prevalence and prognostic implications of dyskinesia developing after exercise.BACKGROUND The prevalence and prognostic implications of new-onset dyskinesia with exercise testing have not been previously described.METHODS We considered 1,005 consecutive patients who underwent exercise echocardiography and had akinetic segments at rest. Patients were divided according to the presence or absence of exercise-induced dyskinesia. Baseline clinical and echocardiographic parameters were compared, and patients were followed up for a median of 2.7 years.RESULTS One hundred four (10%) patients developed dyskinesia after exercise. Compared to patients with segments that remained akinetic, these patients were more likely to have electrocardiographic (ECG) evidence of prior myocardial infarction and, during exercise, had a less pronounced rise in systolic blood pressure and more often had ECG evidence of ischemia. Their resting left ventricular (LV) ejection fraction was worse and improved little after exercise. However, all-cause mortality and the incidence of major adverse cardiac events were similar in the two groups, even after correction for age, gender, and resting LV function (hazard ratio for major adverse cardiac events = 1.36, 95% confidence interval [Cl] 0.82 to 2.26, p = 0.23; hazard ratio for total mortality = 1.20, 95% CI 0.75 to 1.94, p = 0.45).CONCLUSIONS One in 10 patients with akinetic myocardium at rest will develop dyskinesia after exercise. This is associated with poorer LV function at rest and little improvement in systolic function after exercise. However, this response has no impact on prognosis. (C) 2004 by the American College of Cardiology Foundation.

    KW - DOBUTAMINE STRESS ECHOCARDIOGRAPHY

    KW - CORONARY-ARTERY-DISEASE

    KW - MYOCARDIAL-ISCHEMIA

    KW - PROGNOSTIC VALUE

    U2 - 10.1016/j.jacc.2003.08.053

    DO - 10.1016/j.jacc.2003.08.053

    M3 - Article

    VL - 43

    SP - 599

    EP - 605

    JO - Journal of the American College of Cardiology

    JF - Journal of the American College of Cardiology

    SN - 0735-1097

    ER -