Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Gioia Di Credico; Jerry Polesel; Luigino Dal Maso; Francesco Pauli; Nicola Torelli; Daniele Luce; Loredana Radoï; Keitaro Matsuo; Diego Serraino; Paul Brennan; Ivana Holcatova; Wolfgang Ahrens; Pagona Lagiou; Cristina Canova; Lorenzo Richiardi; Claire M Healy; Kristina Kjaerheim; David I Conway; Gary J Macfarlane; Peter Thomson; Antonio Agudo; Ariana Znaor; Silvia Franceschi; Rolando Herrero; Tatiana N Toporcov; Raquel A Moyses; Joshua Muscat; Eva Negri; Marta Vilensky; Leticia Fernandez; Maria Paula Curado; Ana Menezes; Alexander W Daudt; Rosalina Koifman; Victor Wunsch-Filho; Andrew F Olshan; Jose P Zevallos; Erich M Sturgis; Guojun Li; Fabio Levi; Zuo-Feng Zhang; Hal Morgenstern; Elaine Smith; Philip Lazarus; Carlo La Vecchia; Werner Garavello; Chu Chen; Stephen M Schwartz; Tongzhang Zheng; Thomas L Vaughan; Karl Kelsey; Michael McClean; Simone Benhamou; Richard B Hayes; Mark P Purdue; Maura Gillison; Stimson Schantz; Guo-Pei Yu; Shu-Chun Chuang; Paolo Boffetta; Mia Hashibe; Amy Lee Yuan-Chin; Valeria Edefonti

doi:10.1038/s41416-020-01031-z

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Gioia Di Credico, Jerry Polesel^* (Corresponding Author), Luigino Dal Maso^* (Corresponding Author), Francesco Pauli, Nicola Torelli, Daniele Luce, Loredana Radoï, Keitaro Matsuo, Diego Serraino, Paul Brennan, Ivana Holcatova, Wolfgang Ahrens, Pagona Lagiou, Cristina Canova, Lorenzo Richiardi, Claire M Healy, Kristina Kjaerheim, David I Conway, Gary J Macfarlane, Peter ThomsonAntonio Agudo, Ariana Znaor, Silvia Franceschi, Rolando Herrero, Tatiana N Toporcov, Raquel A Moyses, Joshua Muscat, Eva Negri, Marta Vilensky, Leticia Fernandez, Maria Paula Curado, Ana Menezes, Alexander W Daudt, Rosalina Koifman, Victor Wunsch-Filho, Andrew F Olshan, Jose P Zevallos, Erich M Sturgis, Guojun Li, Fabio Levi, Zuo-Feng Zhang, Hal Morgenstern, Elaine Smith, Philip Lazarus, Carlo La Vecchia, Werner Garavello, Chu Chen, Stephen M Schwartz, Tongzhang Zheng, Thomas L Vaughan, Karl Kelsey, Michael McClean, Simone Benhamou, Richard B Hayes, Mark P Purdue, Maura Gillison, Stimson Schantz, Guo-Pei Yu, Shu-Chun Chuang, Paolo Boffetta, Mia Hashibe, Amy Lee Yuan-Chin, Valeria Edefonti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.

METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.

RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).

CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Original language	English
Pages (from-to)	1456-1463
Number of pages	8
Journal	British Journal of Cancer
Volume	123
Early online date	24 Aug 2020
DOIs	https://doi.org/10.1038/s41416-020-01031-z
Publication status	Published - 27 Oct 2020

Bibliographical note

Acknowledgements
We would like to thank Xavier Castellsague, who collected data in the IARC International Multicenter study and passed away in 2016. We thank Mrs Luigina Mei for editorial assistance

Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).

Keywords

SQUAMOUS-CELL CARCINOMA
HUMAN-PAPILLOMAVIRUS
CIGARETTE-SMOKING
ORAL-CANCER
POOLED ANALYSIS
GENETIC SUSCEPTIBILITY
TOTAL EXPOSURE
CONSUMPTION
TOBACCO
POLYMORPHISMS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Di Credico, G., Polesel, J., Dal Maso, L., Pauli, F., Torelli, N., Luce, D., Radoï, L., Matsuo, K., Serraino, D., Brennan, P., Holcatova, I., Ahrens, W., Lagiou, P., Canova, C., Richiardi, L., Healy, C. M., Kjaerheim, K., Conway, D. I., Macfarlane, G. J., ... Edefonti, V. (2020). Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration. British Journal of Cancer, 123, 1456-1463. https://doi.org/10.1038/s41416-020-01031-z

Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoï, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, CM, Kjaerheim, K, Conway, DI, Macfarlane, GJ, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, TN, Moyses, RA, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, MP, Menezes, A, Daudt, AW, Koifman, R, Wunsch-Filho, V, Olshan, AF, Zevallos, JP, Sturgis, EM, Li, G, Levi, F, Zhang, Z-F, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, SM, Zheng, T, Vaughan, TL, Kelsey, K, McClean, M, Benhamou, S, Hayes, RB, Purdue, MP, Gillison, M, Schantz, S, Yu, G-P, Chuang, S-C, Boffetta, P, Hashibe, M, Yuan-Chin, AL & Edefonti, V 2020, 'Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration', British Journal of Cancer, vol. 123, pp. 1456-1463. https://doi.org/10.1038/s41416-020-01031-z

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abstract = "BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.",

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note = "Acknowledgements We would like to thank Xavier Castellsague, who collected data in the IARC International Multicenter study and passed away in 2016. We thank Mrs Luigina Mei for editorial assistance Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0). ",

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TY - JOUR

T1 - Alcohol drinking and head and neck cancer risk

T2 - the joint effect of intensity and duration

AU - Di Credico, Gioia

AU - Polesel, Jerry

AU - Dal Maso, Luigino

AU - Pauli, Francesco

AU - Torelli, Nicola

AU - Luce, Daniele

AU - Radoï, Loredana

AU - Matsuo, Keitaro

AU - Serraino, Diego

AU - Brennan, Paul

AU - Holcatova, Ivana

AU - Ahrens, Wolfgang

AU - Lagiou, Pagona

AU - Canova, Cristina

AU - Richiardi, Lorenzo

AU - Healy, Claire M

AU - Kjaerheim, Kristina

AU - Conway, David I

AU - Macfarlane, Gary J

AU - Thomson, Peter

AU - Agudo, Antonio

AU - Znaor, Ariana

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Toporcov, Tatiana N

AU - Moyses, Raquel A

AU - Muscat, Joshua

AU - Negri, Eva

AU - Vilensky, Marta

AU - Fernandez, Leticia

AU - Curado, Maria Paula

AU - Menezes, Ana

AU - Daudt, Alexander W

AU - Koifman, Rosalina

AU - Wunsch-Filho, Victor

AU - Olshan, Andrew F

AU - Zevallos, Jose P

AU - Sturgis, Erich M

AU - Li, Guojun

AU - Levi, Fabio

AU - Zhang, Zuo-Feng

AU - Morgenstern, Hal

AU - Smith, Elaine

AU - Lazarus, Philip

AU - La Vecchia, Carlo

AU - Garavello, Werner

AU - Chen, Chu

AU - Schwartz, Stephen M

AU - Zheng, Tongzhang

AU - Vaughan, Thomas L

AU - Kelsey, Karl

AU - McClean, Michael

AU - Benhamou, Simone

AU - Hayes, Richard B

AU - Purdue, Mark P

AU - Gillison, Maura

AU - Schantz, Stimson

AU - Yu, Guo-Pei

AU - Chuang, Shu-Chun

AU - Boffetta, Paolo

AU - Hashibe, Mia

AU - Yuan-Chin, Amy Lee

AU - Edefonti, Valeria

N1 - Acknowledgements We would like to thank Xavier Castellsague, who collected data in the IARC International Multicenter study and passed away in 2016. We thank Mrs Luigina Mei for editorial assistance Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0).

PY - 2020/10/27

Y1 - 2020/10/27

N2 - BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

AB - BACKGROUND: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.METHODS: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.RESULTS: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).CONCLUSIONS: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

KW - SQUAMOUS-CELL CARCINOMA

KW - HUMAN-PAPILLOMAVIRUS

KW - CIGARETTE-SMOKING

KW - ORAL-CANCER

KW - POOLED ANALYSIS

KW - GENETIC SUSCEPTIBILITY

KW - TOTAL EXPOSURE

KW - CONSUMPTION

KW - TOBACCO

KW - POLYMORPHISMS

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U2 - 10.1038/s41416-020-01031-z

DO - 10.1038/s41416-020-01031-z

M3 - Article

C2 - 32830199

SN - 0007-0920

VL - 123

SP - 1456

EP - 1463

JO - British Journal of Cancer

JF - British Journal of Cancer

ER -

Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Abstract

Bibliographical note

Keywords

UN SDGs

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