alpha-1-microglobulin: epidemiological indicator for tubular dysfunction induced by cadmium?

T Pless-Mulloli, M Boettcher, M Steiner, J Berger

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objectives-To evaluate the suitability of a-l-microglobulin as a marker for cadmium induced renal dysfunction.

Methods-alpha-1-Microglobulin was studied in a cross sectional survey in relation to the body burden of cadmium. Concentrations of a-l-microglobulin in 24 h urine of 831 people aged 2-87 years were analysed in association with urinary cadmium excretion, cadmium blood concentration, age, sex, occupational and smoking history, and estimated creatinine clearance. Participants came from a population residentially exposed to cadmium and from two control populations matched for socioeconomic status.

Results The excretion of alpha-1-microglobulin 1 24 h ranged from 0.1 mg to 176.3 mg and 44.4% of samples showed concentrations near the detection limit. Ordinal logistic regression analysis of people of all ages identified a high risk only for males compared with females (odds ratio (OR) 2.14; 95% confidence interval (95% CI) 1.56 to 2.94), age group, and duration of Living on contaminated soil (OR 1.03 1 year; 95% CI 1.02 to 1.04), but not urinary cadmium excretion (OR 1.30; 95% CI 0.96 to 1.77) as significant predictors. For people less than or equal to 50 years of age a weaker effect of sex (OR 1.76; 95% CI 1.13 to 2.73) and age group and an effect of similar magnitude for the duration of soil exposure (OR 1.03; 95% CI 1.01 to 1.04) were found. Also, the urinary cadmium excretion (OR 2.26; 95% CI 1.38 to 3.70) and occupational exposure (OR 1.71; 95% CI 1.03 to 2.83) were found to be significant in this younger age group. The estimated creatinine clearance had no significant impact on the alpha-1-microglobulin excretion.

Conclusion-alpha-1-Microglobulin is a suitable marker for early tubular changes only for people less than or equal to 50 years. It may not be sufficiently specific for cadmium, and therefore not a suitable surrogate for cadmium exposure in epidemiological studies.

Original languageEnglish
Pages (from-to)440-445
Number of pages6
JournalOccupational and Environmental Medicine
Volume55
Issue number7
Publication statusPublished - Jul 1998

Keywords

  • alpha-1-microglobulin
  • cadmium
  • marker
  • renal dysfunction
  • RENAL CHANGES
  • INDUSTRIAL POLLUTANTS
  • EXPOSURE
  • WORKERS
  • MARKERS
  • URINE
  • LEAD
  • BETA2-MICROGLOBULIN
  • NEPHROTOXICITY
  • MICROGLOBULIN

Cite this

alpha-1-microglobulin: epidemiological indicator for tubular dysfunction induced by cadmium? / Pless-Mulloli, T ; Boettcher, M ; Steiner, M ; Berger, J .

In: Occupational and Environmental Medicine, Vol. 55, No. 7, 07.1998, p. 440-445.

Research output: Contribution to journalArticle

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title = "alpha-1-microglobulin: epidemiological indicator for tubular dysfunction induced by cadmium?",
abstract = "Objectives-To evaluate the suitability of a-l-microglobulin as a marker for cadmium induced renal dysfunction.Methods-alpha-1-Microglobulin was studied in a cross sectional survey in relation to the body burden of cadmium. Concentrations of a-l-microglobulin in 24 h urine of 831 people aged 2-87 years were analysed in association with urinary cadmium excretion, cadmium blood concentration, age, sex, occupational and smoking history, and estimated creatinine clearance. Participants came from a population residentially exposed to cadmium and from two control populations matched for socioeconomic status.Results The excretion of alpha-1-microglobulin 1 24 h ranged from 0.1 mg to 176.3 mg and 44.4{\%} of samples showed concentrations near the detection limit. Ordinal logistic regression analysis of people of all ages identified a high risk only for males compared with females (odds ratio (OR) 2.14; 95{\%} confidence interval (95{\%} CI) 1.56 to 2.94), age group, and duration of Living on contaminated soil (OR 1.03 1 year; 95{\%} CI 1.02 to 1.04), but not urinary cadmium excretion (OR 1.30; 95{\%} CI 0.96 to 1.77) as significant predictors. For people less than or equal to 50 years of age a weaker effect of sex (OR 1.76; 95{\%} CI 1.13 to 2.73) and age group and an effect of similar magnitude for the duration of soil exposure (OR 1.03; 95{\%} CI 1.01 to 1.04) were found. Also, the urinary cadmium excretion (OR 2.26; 95{\%} CI 1.38 to 3.70) and occupational exposure (OR 1.71; 95{\%} CI 1.03 to 2.83) were found to be significant in this younger age group. The estimated creatinine clearance had no significant impact on the alpha-1-microglobulin excretion.Conclusion-alpha-1-Microglobulin is a suitable marker for early tubular changes only for people less than or equal to 50 years. It may not be sufficiently specific for cadmium, and therefore not a suitable surrogate for cadmium exposure in epidemiological studies.",
keywords = "alpha-1-microglobulin, cadmium, marker, renal dysfunction, RENAL CHANGES, INDUSTRIAL POLLUTANTS, EXPOSURE, WORKERS, MARKERS, URINE, LEAD, BETA2-MICROGLOBULIN, NEPHROTOXICITY, MICROGLOBULIN",
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T1 - alpha-1-microglobulin: epidemiological indicator for tubular dysfunction induced by cadmium?

AU - Pless-Mulloli, T

AU - Boettcher, M

AU - Steiner, M

AU - Berger, J

PY - 1998/7

Y1 - 1998/7

N2 - Objectives-To evaluate the suitability of a-l-microglobulin as a marker for cadmium induced renal dysfunction.Methods-alpha-1-Microglobulin was studied in a cross sectional survey in relation to the body burden of cadmium. Concentrations of a-l-microglobulin in 24 h urine of 831 people aged 2-87 years were analysed in association with urinary cadmium excretion, cadmium blood concentration, age, sex, occupational and smoking history, and estimated creatinine clearance. Participants came from a population residentially exposed to cadmium and from two control populations matched for socioeconomic status.Results The excretion of alpha-1-microglobulin 1 24 h ranged from 0.1 mg to 176.3 mg and 44.4% of samples showed concentrations near the detection limit. Ordinal logistic regression analysis of people of all ages identified a high risk only for males compared with females (odds ratio (OR) 2.14; 95% confidence interval (95% CI) 1.56 to 2.94), age group, and duration of Living on contaminated soil (OR 1.03 1 year; 95% CI 1.02 to 1.04), but not urinary cadmium excretion (OR 1.30; 95% CI 0.96 to 1.77) as significant predictors. For people less than or equal to 50 years of age a weaker effect of sex (OR 1.76; 95% CI 1.13 to 2.73) and age group and an effect of similar magnitude for the duration of soil exposure (OR 1.03; 95% CI 1.01 to 1.04) were found. Also, the urinary cadmium excretion (OR 2.26; 95% CI 1.38 to 3.70) and occupational exposure (OR 1.71; 95% CI 1.03 to 2.83) were found to be significant in this younger age group. The estimated creatinine clearance had no significant impact on the alpha-1-microglobulin excretion.Conclusion-alpha-1-Microglobulin is a suitable marker for early tubular changes only for people less than or equal to 50 years. It may not be sufficiently specific for cadmium, and therefore not a suitable surrogate for cadmium exposure in epidemiological studies.

AB - Objectives-To evaluate the suitability of a-l-microglobulin as a marker for cadmium induced renal dysfunction.Methods-alpha-1-Microglobulin was studied in a cross sectional survey in relation to the body burden of cadmium. Concentrations of a-l-microglobulin in 24 h urine of 831 people aged 2-87 years were analysed in association with urinary cadmium excretion, cadmium blood concentration, age, sex, occupational and smoking history, and estimated creatinine clearance. Participants came from a population residentially exposed to cadmium and from two control populations matched for socioeconomic status.Results The excretion of alpha-1-microglobulin 1 24 h ranged from 0.1 mg to 176.3 mg and 44.4% of samples showed concentrations near the detection limit. Ordinal logistic regression analysis of people of all ages identified a high risk only for males compared with females (odds ratio (OR) 2.14; 95% confidence interval (95% CI) 1.56 to 2.94), age group, and duration of Living on contaminated soil (OR 1.03 1 year; 95% CI 1.02 to 1.04), but not urinary cadmium excretion (OR 1.30; 95% CI 0.96 to 1.77) as significant predictors. For people less than or equal to 50 years of age a weaker effect of sex (OR 1.76; 95% CI 1.13 to 2.73) and age group and an effect of similar magnitude for the duration of soil exposure (OR 1.03; 95% CI 1.01 to 1.04) were found. Also, the urinary cadmium excretion (OR 2.26; 95% CI 1.38 to 3.70) and occupational exposure (OR 1.71; 95% CI 1.03 to 2.83) were found to be significant in this younger age group. The estimated creatinine clearance had no significant impact on the alpha-1-microglobulin excretion.Conclusion-alpha-1-Microglobulin is a suitable marker for early tubular changes only for people less than or equal to 50 years. It may not be sufficiently specific for cadmium, and therefore not a suitable surrogate for cadmium exposure in epidemiological studies.

KW - alpha-1-microglobulin

KW - cadmium

KW - marker

KW - renal dysfunction

KW - RENAL CHANGES

KW - INDUSTRIAL POLLUTANTS

KW - EXPOSURE

KW - WORKERS

KW - MARKERS

KW - URINE

KW - LEAD

KW - BETA2-MICROGLOBULIN

KW - NEPHROTOXICITY

KW - MICROGLOBULIN

M3 - Article

VL - 55

SP - 440

EP - 445

JO - Occupational and Environmental Medicine

JF - Occupational and Environmental Medicine

SN - 1351-0711

IS - 7

ER -