Alterations in plasma lipids, lipoproteins and high density lipoprotein subfractions in peripheral arterial disease

Beverley F. Mowat*, E. Roy Skinner, Heather M. Wilson, Gillian C. Leng, F. Gerald R. Fowkes, David Horrobin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

The concentrations of the major lipoprotein classes and of high density lipoprotein (HDL) subfractions in 63 male patients with arteriosclerosis of the lower limbs (claudication) were determined and compared with values from 63 healthy controls. The patients with peripheral arterial disease (PAD) had reduced levels of total HDL-cholesterol and HDL(2b) of large particle size, increased levels of small HDL(3C) particles and a high ratio of total plasma-cholesterol to HDL-cholesterol (coronary risk factor). The PAD patients, however, had lower levels of low density lipoprotein (LDL)-cholesterol but higher concentrations of very low density lipoprotein (VLDL)-cholesterol and plasma triglyceride than healthy subjects. This study therefore suggests that in PAD, the protective effect of HDL may be more important than the atherogenic effect of LDL. It further suggests that while HDL-cholesterol HDL(2b) and the ratio of total plasma-cholesterol to HDL-cholesterol may provide valid indices for identifying individuals at risk of PAD, other factors, such as LDL and total cholesterol, may not provide such an appropriate risk indicator.

Original languageEnglish
Pages (from-to)161-166
Number of pages6
JournalAtherosclerosis
Volume131
Issue number2
DOIs
Publication statusPublished - 30 Jun 1997

Keywords

  • High density lipoprotein
  • High density lipoprotein subfractions
  • Lipoproteins
  • Low density lipoprotein
  • Peripheral arterial disease

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