Alterations in vitamin A/retinoic acid homeostasis in diet-induced obesity and insulin resistance

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Abstract

Vitamin A is an essential micronutrient for life and the phytochemical β-carotene, also known as pro-vitamin A, is an important dietary source of this vitamin. Vitamin A (retinol) is the parent compound of all bioactive retinoids but it is retinoic acid (RA) that is the active metabolite of vitamin A. The plasma concentration of retinol is maintained in a narrow range and its normal biological activities strictly regulated since excessive intake can lead to toxicity and thus also be detrimental to life. The present review will give an overview of how vitamin A homeostasis is maintained and move on to focus on the link between circulating vitamin A and metabolic disease states. Finally, we will examine how pharmacological or genetic alterations in vitamin A homeostasis and RA-signalling can influence body fat and blood glucose levels including a novel link to the liver secreted hormone fibroblast growth factor 21, an important metabolic regulator.

Original languageEnglish
Pages (from-to)597-602
Number of pages6
JournalProceedings of the Nutrition Society
Volume76
Issue number4
Early online date27 Jun 2017
DOIs
Publication statusPublished - Nov 2017
EventNutrition Society Scottish Section Conference on ‘Phytochemicals and health: new perspectives on plant-based nutrition’: Symposium 3: Phytochemicals for healthier foods - The Royal College of Physicians, Edinburgh, United Kingdom
Duration: 21 Mar 201622 Mar 2016

Keywords

  • Retinoids
  • Adiposity
  • Glucose homeostasis
  • Ceramide
  • Fibroblast growth factor 21

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