Altered hippocampal function in major depression despite intact structure and resting perfusion

A. Finkelmeyer, J. Nilsson, J. He, L. Stevens, J. J. Maller, R. A. Moss, S. Small, P. Gallagher, K. Coventry, I. N. Ferrier, R. H. McAllister-Williams

Research output: Contribution to journalArticle

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Abstract

Background. Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal function
in depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation.
Method. A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memory
task, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed.
Results. The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow.
Conclusions. Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression.
Original languageEnglish
Pages (from-to)2157-2168
Number of pages12
JournalPsychological Medicine
Volume46
Issue number10
Early online date19 May 2016
DOIs
Publication statusPublished - Jul 2016

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Perfusion
Magnetic Resonance Imaging
Depression
Hippocampus
Major Depressive Disorder
Blood Volume
Neuropsychological Tests
Research Design
Oxygen
Spatial Memory

Keywords

  • hippocampus
  • magnetic resonance imaging
  • major depressive disorder
  • spatial memory

Cite this

Finkelmeyer, A., Nilsson, J., He, J., Stevens, L., Maller, J. J., Moss, R. A., ... McAllister-Williams, R. H. (2016). Altered hippocampal function in major depression despite intact structure and resting perfusion. Psychological Medicine, 46(10), 2157-2168. https://doi.org/10.1017/S0033291716000702

Altered hippocampal function in major depression despite intact structure and resting perfusion. / Finkelmeyer, A.; Nilsson, J.; He, J.; Stevens, L.; Maller, J. J.; Moss, R. A.; Small, S. ; Gallagher, P.; Coventry, K.; Ferrier, I. N.; McAllister-Williams, R. H.

In: Psychological Medicine, Vol. 46, No. 10, 07.2016, p. 2157-2168.

Research output: Contribution to journalArticle

Finkelmeyer, A, Nilsson, J, He, J, Stevens, L, Maller, JJ, Moss, RA, Small, S, Gallagher, P, Coventry, K, Ferrier, IN & McAllister-Williams, RH 2016, 'Altered hippocampal function in major depression despite intact structure and resting perfusion' Psychological Medicine, vol. 46, no. 10, pp. 2157-2168. https://doi.org/10.1017/S0033291716000702
Finkelmeyer, A. ; Nilsson, J. ; He, J. ; Stevens, L. ; Maller, J. J. ; Moss, R. A. ; Small, S. ; Gallagher, P. ; Coventry, K. ; Ferrier, I. N. ; McAllister-Williams, R. H. / Altered hippocampal function in major depression despite intact structure and resting perfusion. In: Psychological Medicine. 2016 ; Vol. 46, No. 10. pp. 2157-2168.
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abstract = "Background. Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal functionin depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation.Method. A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memorytask, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed.Results. The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow.Conclusions. Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression.",
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note = "Acknowledgements We graciously acknowledge the help of the staff of the Newcastle Magnetic Resonance Centre, Newcastle University, in conducting this research. A.F. is supported by Research Capability Funding from the Northumberland-Tyne-and-Wear NHS Foundation Trust awarded to R.H.M.-W.",
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AU - Finkelmeyer, A.

AU - Nilsson, J.

AU - He, J.

AU - Stevens, L.

AU - Maller, J. J.

AU - Moss, R. A.

AU - Small, S.

AU - Gallagher, P.

AU - Coventry, K.

AU - Ferrier, I. N.

AU - McAllister-Williams, R. H.

N1 - Acknowledgements We graciously acknowledge the help of the staff of the Newcastle Magnetic Resonance Centre, Newcastle University, in conducting this research. A.F. is supported by Research Capability Funding from the Northumberland-Tyne-and-Wear NHS Foundation Trust awarded to R.H.M.-W.

PY - 2016/7

Y1 - 2016/7

N2 - Background. Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal functionin depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation.Method. A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memorytask, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed.Results. The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow.Conclusions. Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression.

AB - Background. Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear. We investigated hippocampal functionin depression using functional magnetic resonance imaging (fMRI) and neuropsychological tasks tapping spatial memory function, with complementing measures of hippocampal volume and resting blood flow to aid interpretation.Method. A total of 20 patients with major depressive disorder (MDD) and a matched group of 20 healthy individuals participated. Participants underwent multimodal magnetic resonance imaging (MRI): fMRI during a spatial memorytask, and structural MRI and resting blood flow measurements of the hippocampal region using arterial spin labelling. An offline battery of neuropsychological tests, including several measures of spatial memory, was also completed.Results. The fMRI analysis showed significant group differences in bilateral anterior regions of the hippocampus. While control participants showed task-dependent differences in blood oxygen level-dependent (BOLD) signal, depressed patients did not. No group differences were detected with regard to hippocampal volume or resting blood flow. Patients showed reduced performance in several offline neuropsychological measures. All group differences were independent of differences in hippocampal volume and hippocampal blood flow.Conclusions. Functional abnormalities of the hippocampus can be observed in patients with MDD even when the volume and resting perfusion in the same region appear normal. This suggests that changes in hippocampal function can be observed independently of structural abnormalities of the hippocampus in depression.

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KW - magnetic resonance imaging

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