Alternation between short- and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (Phodopus sungorus)

Jonathan H. H. Bank, Dana Wilson, Eddy Rijntjes, Perry Barrett, Annika Herwig

Research output: Contribution to journalArticle

3 Citations (Scopus)
4 Downloads (Pure)

Abstract

Djungarian hamsters are able to reduce their body weight by more than 30% in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and conserved under laboratory conditions. We used this animal model to investigate hypothalamic gene expression linked to body weight regulation behind this physiological phenomenon. After an initial collective short photoperiod (SP) adaptation for 14 weeks from a preceding long photoperiod (LP), hamsters were re-exposed to LP for either six or 14 weeks, followed by a second re-exposure to SP for eight weeks. Our data showed that re-exposure to LP led to an increase in body weight. In the hypothalamus Dio2, Vimentin, Crbp1 and Grp50 expression increased, but expression of Dio3, Mct8 and Srif decreased. The changes in body weight and gene expression were reversible in most hamsters after a further re-exposure to SP following six or 14 weeks in LP. Interestingly, body weight loss was pronounced in six hamsters re-exposed to SP after 14 weeks in LP, while five hamsters did not respond to SP. In non-responding hamsters, a different gene expression pattern was manifested, with the exception of Dio2 which was reduced not only in SP re-exposed hamsters but also hamsters maintained in LP. Together these data suggest that body weight regulation seems to be tightly linked to a co-ordinated regulation of several genes in the hypothalamus including those involved in thyroid hormone metabolism.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalJournal of Neuroendocrinology
Volume29
Issue number7
Early online date2 Jul 2017
DOIs
Publication statusPublished - Jul 2017

Fingerprint

Phodopus
Body Weight Changes
Photoperiod
Cricetinae
Genes
Body Weight
Gene Expression
Hypothalamus
Physiological Phenomena
Vimentin
Thyroid Hormones

Keywords

  • Siberian hamster
  • thyroid hormone
  • retinoic acid
  • Gpr50
  • somatostatin

Cite this

@article{f330e65bb55e455c903d5978909ce41a,
title = "Alternation between short- and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (Phodopus sungorus)",
abstract = "Djungarian hamsters are able to reduce their body weight by more than 30{\%} in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and conserved under laboratory conditions. We used this animal model to investigate hypothalamic gene expression linked to body weight regulation behind this physiological phenomenon. After an initial collective short photoperiod (SP) adaptation for 14 weeks from a preceding long photoperiod (LP), hamsters were re-exposed to LP for either six or 14 weeks, followed by a second re-exposure to SP for eight weeks. Our data showed that re-exposure to LP led to an increase in body weight. In the hypothalamus Dio2, Vimentin, Crbp1 and Grp50 expression increased, but expression of Dio3, Mct8 and Srif decreased. The changes in body weight and gene expression were reversible in most hamsters after a further re-exposure to SP following six or 14 weeks in LP. Interestingly, body weight loss was pronounced in six hamsters re-exposed to SP after 14 weeks in LP, while five hamsters did not respond to SP. In non-responding hamsters, a different gene expression pattern was manifested, with the exception of Dio2 which was reduced not only in SP re-exposed hamsters but also hamsters maintained in LP. Together these data suggest that body weight regulation seems to be tightly linked to a co-ordinated regulation of several genes in the hypothalamus including those involved in thyroid hormone metabolism.",
keywords = "Siberian hamster, thyroid hormone, retinoic acid, Gpr50, somatostatin",
author = "Bank, {Jonathan H. H.} and Dana Wilson and Eddy Rijntjes and Perry Barrett and Annika Herwig",
note = "This work was funded by the German Research Foundation (DFG, Emmy-Noether HE6383 to AH) and the British Society for Neuroendocrinology (Research grant to JB). The authors declare that they have no conflicts of interest.",
year = "2017",
month = "7",
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TY - JOUR

T1 - Alternation between short- and long photoperiod reveals hypothalamic gene regulation linked to seasonal body weight changes in Djungarian hamsters (Phodopus sungorus)

AU - Bank, Jonathan H. H.

AU - Wilson, Dana

AU - Rijntjes, Eddy

AU - Barrett, Perry

AU - Herwig, Annika

N1 - This work was funded by the German Research Foundation (DFG, Emmy-Noether HE6383 to AH) and the British Society for Neuroendocrinology (Research grant to JB). The authors declare that they have no conflicts of interest.

PY - 2017/7

Y1 - 2017/7

N2 - Djungarian hamsters are able to reduce their body weight by more than 30% in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and conserved under laboratory conditions. We used this animal model to investigate hypothalamic gene expression linked to body weight regulation behind this physiological phenomenon. After an initial collective short photoperiod (SP) adaptation for 14 weeks from a preceding long photoperiod (LP), hamsters were re-exposed to LP for either six or 14 weeks, followed by a second re-exposure to SP for eight weeks. Our data showed that re-exposure to LP led to an increase in body weight. In the hypothalamus Dio2, Vimentin, Crbp1 and Grp50 expression increased, but expression of Dio3, Mct8 and Srif decreased. The changes in body weight and gene expression were reversible in most hamsters after a further re-exposure to SP following six or 14 weeks in LP. Interestingly, body weight loss was pronounced in six hamsters re-exposed to SP after 14 weeks in LP, while five hamsters did not respond to SP. In non-responding hamsters, a different gene expression pattern was manifested, with the exception of Dio2 which was reduced not only in SP re-exposed hamsters but also hamsters maintained in LP. Together these data suggest that body weight regulation seems to be tightly linked to a co-ordinated regulation of several genes in the hypothalamus including those involved in thyroid hormone metabolism.

AB - Djungarian hamsters are able to reduce their body weight by more than 30% in anticipation of the winter season. This particular adaptation to extreme environmental conditions is primarily driven by a natural reduction in day length and conserved under laboratory conditions. We used this animal model to investigate hypothalamic gene expression linked to body weight regulation behind this physiological phenomenon. After an initial collective short photoperiod (SP) adaptation for 14 weeks from a preceding long photoperiod (LP), hamsters were re-exposed to LP for either six or 14 weeks, followed by a second re-exposure to SP for eight weeks. Our data showed that re-exposure to LP led to an increase in body weight. In the hypothalamus Dio2, Vimentin, Crbp1 and Grp50 expression increased, but expression of Dio3, Mct8 and Srif decreased. The changes in body weight and gene expression were reversible in most hamsters after a further re-exposure to SP following six or 14 weeks in LP. Interestingly, body weight loss was pronounced in six hamsters re-exposed to SP after 14 weeks in LP, while five hamsters did not respond to SP. In non-responding hamsters, a different gene expression pattern was manifested, with the exception of Dio2 which was reduced not only in SP re-exposed hamsters but also hamsters maintained in LP. Together these data suggest that body weight regulation seems to be tightly linked to a co-ordinated regulation of several genes in the hypothalamus including those involved in thyroid hormone metabolism.

KW - Siberian hamster

KW - thyroid hormone

KW - retinoic acid

KW - Gpr50

KW - somatostatin

U2 - 10.1111/jne.12487

DO - 10.1111/jne.12487

M3 - Article

VL - 29

SP - 1

EP - 11

JO - Journal of Neuroendocrinology

JF - Journal of Neuroendocrinology

SN - 0953-8194

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ER -