Alzheimer disease as a vascular disorder: where do mitochondria fit?

Sónia C Correia, Renato X Santos, Susana Cardoso, Cristina Carvalho, Emanuel Candeias, Ana I Duarte, Ana I Plácido, Maria S Santos, Paula I Moreira

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Although the precise culprit in the etiopathogenesis of Alzheimer disease (AD) is still obscure, defective mitochondria functioning has been proposed to be an upstream event in AD. Mitochondria fulfill a number of essential cellular functions, and it is recognized that the strict regulation of the structure, function and turnover of these organelles is an immutable control node for the maintenance of neuronal and vascular homeostasis. Extensive research in postmortem brain tissue from AD subjects, and AD animal and cellular models revealed that mitochondria undergo multiple malfunctions during the course of this disease. The present review summarizes the current views on how mitochondria are implicated in both AD-related neuronal and cerebrovascular degeneration. The understanding of the mitochondrial mechanisms underlying AD pathology is critical to design more effective strategies to halt or delay disease progression.

Original languageEnglish
Pages (from-to)878-886
Number of pages9
JournalExperimental Gerontology
Volume47
Issue number11
Early online date20 Jul 2012
DOIs
Publication statusPublished - Nov 2012

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Keywords

  • Alzheimer Disease/physiopathology
  • Animals
  • Cerebrovascular Disorders/physiopathology
  • Disease Models, Animal
  • Disease Progression
  • Humans
  • Mitochondria/pathology
  • Mitochondrial Diseases/physiopathology

Cite this

Correia, S. C., Santos, R. X., Cardoso, S., Carvalho, C., Candeias, E., Duarte, A. I., Plácido, A. I., Santos, M. S., & Moreira, P. I. (2012). Alzheimer disease as a vascular disorder: where do mitochondria fit? Experimental Gerontology, 47(11), 878-886. https://doi.org/10.1016/j.exger.2012.07.006