Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients

Anca-Larisa Sandu, Eric Artiges, André Galinowski, Thierry Gallarda, Frank Bellivier, Hervé Lemaitre, Bernard Granger, Damien Ringuenet, Eleni T Tzavara, Jean-Luc Martinot, Marie-Laure Paillère Martinot

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.

METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.

RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.

CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.

Original languageEnglish
Pages (from-to)1065-1071
Number of pages7
JournalDepression and Anxiety
Volume34
Early online date9 Aug 2017
DOIs
Publication statusPublished - Nov 2017

Fingerprint

Amygdala
Treatment-Resistant Depressive Disorder
Depression
Therapeutics
Brain
Depressive Disorder
Prefrontal Cortex
Bipolar Disorder
Lithium
Magnetic Resonance Spectroscopy
Pharmacology
Gray Matter

Keywords

  • Journal Article
  • biological markers
  • bipolar disorder
  • brain imaging/neuroimaging
  • depression
  • treatment resistance

Cite this

Sandu, A-L., Artiges, E., Galinowski, A., Gallarda, T., Bellivier, F., Lemaitre, H., ... Paillère Martinot, M-L. (2017). Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depression and Anxiety, 34, 1065-1071. https://doi.org/10.1002/da.22675

Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. / Sandu, Anca-Larisa; Artiges, Eric; Galinowski, André; Gallarda, Thierry; Bellivier, Frank; Lemaitre, Hervé; Granger, Bernard; Ringuenet, Damien; Tzavara, Eleni T; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure.

In: Depression and Anxiety, Vol. 34, 11.2017, p. 1065-1071.

Research output: Contribution to journalArticle

Sandu, A-L, Artiges, E, Galinowski, A, Gallarda, T, Bellivier, F, Lemaitre, H, Granger, B, Ringuenet, D, Tzavara, ET, Martinot, J-L & Paillère Martinot, M-L 2017, 'Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients' Depression and Anxiety, vol. 34, pp. 1065-1071. https://doi.org/10.1002/da.22675
Sandu, Anca-Larisa ; Artiges, Eric ; Galinowski, André ; Gallarda, Thierry ; Bellivier, Frank ; Lemaitre, Hervé ; Granger, Bernard ; Ringuenet, Damien ; Tzavara, Eleni T ; Martinot, Jean-Luc ; Paillère Martinot, Marie-Laure. / Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. In: Depression and Anxiety. 2017 ; Vol. 34. pp. 1065-1071.
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AU - Paillère Martinot, Marie-Laure

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