Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients

Anca-Larisa Sandu; Eric Artiges; André Galinowski; Thierry Gallarda; Frank Bellivier; Hervé Lemaitre; Bernard Granger; Damien Ringuenet; Eleni T Tzavara; Jean-Luc Martinot; Marie-Laure Paillère Martinot

doi:10.1002/da.22675

Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients

Anca-Larisa Sandu, Eric Artiges, André Galinowski, Thierry Gallarda, Frank Bellivier, Hervé Lemaitre, Bernard Granger, Damien Ringuenet, Eleni T Tzavara, Jean-Luc Martinot, Marie-Laure Paillère Martinot

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Abstract

BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.

METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.

RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.

CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.

Original language	English
Pages (from-to)	1065-1071
Number of pages	7
Journal	Depression and Anxiety
Volume	34
Early online date	9 Aug 2017
DOIs	https://doi.org/10.1002/da.22675
Publication status	Published - Nov 2017

Keywords

Journal Article
biological markers
bipolar disorder
brain imaging/neuroimaging
depression
treatment resistance

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Accepted Manuscript
This is the peer reviewed version of the following article:Sandu A-L, Artiges E, Galinowski A, et. al. Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. Depress Anxiety. 2017;34:1065–1071., which has been published in final form at DOI: 10.1002/da.22675. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 192 KBLicence: Unspecified

Anca-Larisa Sandu-Giuraniuc
Person: Academic

Cite this

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title = "Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients",

abstract = "BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.",

keywords = "Journal Article, biological markers, bipolar disorder, brain imaging/neuroimaging, depression, treatment resistance",

author = "Anca-Larisa Sandu and Eric Artiges and Andr{\'e} Galinowski and Thierry Gallarda and Frank Bellivier and Herv{\'e} Lemaitre and Bernard Granger and Damien Ringuenet and Tzavara, {Eleni T} and Jean-Luc Martinot and {Paill{\`e}re Martinot}, Marie-Laure",

note = "Funded by •Assistance Publique-H{\^o}pitaux de Paris (AP-HP) and the French Health Ministry. Grant Number: PHRC/AOM-98099 •French Institute for Health and Medical Research (INSERM). Grant Number: INSERM-PROGRES A99013LS ",

year = "2017",

month = nov,

doi = "10.1002/da.22675",

language = "English",

volume = "34",

pages = "1065--1071",

journal = "Depression and Anxiety",

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T1 - Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients

AU - Sandu, Anca-Larisa

AU - Artiges, Eric

AU - Galinowski, André

AU - Gallarda, Thierry

AU - Bellivier, Frank

AU - Lemaitre, Hervé

AU - Granger, Bernard

AU - Ringuenet, Damien

AU - Tzavara, Eleni T

AU - Martinot, Jean-Luc

AU - Paillère Martinot, Marie-Laure

N1 - Funded by •Assistance Publique-Hôpitaux de Paris (AP-HP) and the French Health Ministry. Grant Number: PHRC/AOM-98099 •French Institute for Health and Medical Research (INSERM). Grant Number: INSERM-PROGRES A99013LS

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.

AB - BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.

KW - Journal Article

KW - biological markers

KW - bipolar disorder

KW - brain imaging/neuroimaging

KW - depression

KW - treatment resistance

U2 - 10.1002/da.22675

DO - 10.1002/da.22675

M3 - Article

C2 - 28792656

VL - 34

SP - 1065

EP - 1071

JO - Depression and Anxiety

JF - Depression and Anxiety

SN - 1091-4269

ER -

Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients

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Anca-Larisa Sandu-Giuraniuc

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