Abstract
BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.
METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.
RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.
CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.
| Original language | English |
|---|---|
| Pages (from-to) | 1065-1071 |
| Number of pages | 7 |
| Journal | Depression and Anxiety |
| Volume | 34 |
| Early online date | 9 Aug 2017 |
| DOIs | |
| Publication status | Published - Nov 2017 |
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Keywords
- Journal Article
- biological markers
- bipolar disorder
- brain imaging/neuroimaging
- depression
- treatment resistance
Cite this
Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients. / Sandu, Anca-Larisa; Artiges, Eric; Galinowski, André; Gallarda, Thierry; Bellivier, Frank; Lemaitre, Hervé; Granger, Bernard; Ringuenet, Damien; Tzavara, Eleni T; Martinot, Jean-Luc; Paillère Martinot, Marie-Laure.
In: Depression and Anxiety, Vol. 34, 11.2017, p. 1065-1071.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amygdala and regional volumes in treatment-resistant versus nontreatment-resistant depression patients
AU - Sandu, Anca-Larisa
AU - Artiges, Eric
AU - Galinowski, André
AU - Gallarda, Thierry
AU - Bellivier, Frank
AU - Lemaitre, Hervé
AU - Granger, Bernard
AU - Ringuenet, Damien
AU - Tzavara, Eleni T
AU - Martinot, Jean-Luc
AU - Paillère Martinot, Marie-Laure
N1 - Funded by •Assistance Publique-Hôpitaux de Paris (AP-HP) and the French Health Ministry. Grant Number: PHRC/AOM-98099 •French Institute for Health and Medical Research (INSERM). Grant Number: INSERM-PROGRES A99013LS
PY - 2017/11
Y1 - 2017/11
N2 - BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.
AB - BACKGROUND: Although treatment-resistant and nontreatment-resistant depressed patients show structural brain anomalies relative to healthy controls, the difference in regional volumetry between these two groups remains undocumented.METHODS: A whole-brain voxel-based morphometry (VBM) analysis of regional volumes was performed in 125 participants' magnetic resonance images obtained on a 1.5 Tesla scanner; 41 had treatment-resistant depression (TRD), 40 nontreatment-resistant depression (non-TRD), and 44 were healthy controls. The groups were comparable for age and gender. Bipolar/unipolar features as well as pharmacological treatment classes were taken into account as covariates.RESULTS: TRD patients had higher gray matter (GM) volume in the left and right amygdala than non-TRD patients. No difference was found between the TRD bipolar and the TRD unipolar patients, or between the non-TRD bipolar and non-TRD unipolar patients. An exploratory analysis showed that lithium-treated patients in both groups had higher GM volume in the superior and middle frontal gyri in both hemispheres.CONCLUSIONS: Higher GM volume in amygdala detected in TRD patients might be seen in perspective with vulnerability to chronicity, revealed by medication resistance.
KW - Journal Article
KW - biological markers
KW - bipolar disorder
KW - brain imaging/neuroimaging
KW - depression
KW - treatment resistance
U2 - 10.1002/da.22675
DO - 10.1002/da.22675
M3 - Article
VL - 34
SP - 1065
EP - 1071
JO - Depression and Anxiety
JF - Depression and Anxiety
SN - 1091-4269
ER -