An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial):  A randomised controlled trial.

Liv Freeman; Johanna Middeldorp; Eline Van Den Akker; Martijn Oudijk; Caroline Bax; Marloes Van Huizen; Celine Radder; Bianca Fong; Kitty Bloemenkamp; Albert Dahan; Michel Struys; Ben Willem Mol; Jan Van Lith; Elske Van Den Akker-Van Marle

doi:10.1371/journal.pone.0205220

An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial): A randomised controlled trial.

Liv Freeman^*, Johanna Middeldorp, Eline Van Den Akker, Martijn Oudijk, Caroline Bax, Marloes Van Huizen, Celine Radder, Bianca Fong, Kitty Bloemenkamp, Albert Dahan, Michel Struys, Ben Willem Mol, Jan Van Lith, Elske Van Den Akker-Van Marle

^*Corresponding author for this work

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective To compare the costs of a strategy of patient controlled remifentanil versus epidural analgesia for pain relief in labour. Design We performed a multicentre randomised controlled trial in 15 hospitals in the Netherlands, The RAVEL trial. Costs were analysed from a health care perspective alongside the RAVEL trial. Population Pregnant women of intermediate to high risk beyond 32 weeks gestation who planned vaginal delivery. Methods Women were randomised before the onset of labour, to receive either patient controlled remifentanil or epidural analgesia when pain relief was requested during labour.

Original language	English
Article number	e0205220
Number of pages	13
Journal	PloS ONE
Volume	13
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0205220
Publication status	Published - 11 Oct 2018

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10.1371/journal.pone.0205220Licence: CC BY

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This is an open access article distributed under the terms of the Creative Commons Attribution License, https://creativecommons.org/licenses/by/4.0/which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Freeman, L., Middeldorp, J., Van Den Akker, E., Oudijk, M., Bax, C., Van Huizen, M., Radder, C., Fong, B., Bloemenkamp, K., Dahan, A., Struys, M., Willem Mol, B., Van Lith, J., & Van Den Akker-Van Marle, E. (2018). An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial): A randomised controlled trial. PloS ONE, 13(10), [e0205220]. https://doi.org/10.1371/journal.pone.0205220

Freeman, L, Middeldorp, J, Van Den Akker, E, Oudijk, M, Bax, C, Van Huizen, M, Radder, C, Fong, B, Bloemenkamp, K, Dahan, A, Struys, M, Willem Mol, B, Van Lith, J & Van Den Akker-Van Marle, E 2018, 'An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial): A randomised controlled trial.', PloS ONE, vol. 13, no. 10, e0205220. https://doi.org/10.1371/journal.pone.0205220

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title = "An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial): A randomised controlled trial.",

abstract = "Objective To compare the costs of a strategy of patient controlled remifentanil versus epidural analgesia for pain relief in labour. Design We performed a multicentre randomised controlled trial in 15 hospitals in the Netherlands, The RAVEL trial. Costs were analysed from a health care perspective alongside the RAVEL trial. Population Pregnant women of intermediate to high risk beyond 32 weeks gestation who planned vaginal delivery. Methods Women were randomised before the onset of labour, to receive either patient controlled remifentanil or epidural analgesia when pain relief was requested during labour.",

author = "Liv Freeman and Johanna Middeldorp and {Van Den Akker}, Eline and Martijn Oudijk and Caroline Bax and {Van Huizen}, Marloes and Celine Radder and Bianca Fong and Kitty Bloemenkamp and Albert Dahan and Michel Struys and {Willem Mol}, Ben and {Van Lith}, Jan and {Van Den Akker-Van Marle}, Elske",

note = "Data Availability: The original full data set included possible identifying information (birthdates and patient initials). A edited dataset without these variables is uploaded with this submission. For access to the full and original data set including birthdates and initials Liv Freeman or Johanna Middeldorp can be contacted. Access to the original case report form can also be requested. Funding: Financial support for this trial was provided by ZonMW (Dutch Organization for Health Care Research and Development), the Hague, the Netherlands, project number 80-82310-97-11039. www.zonmw.nl. The grant applicant was JM, the funding was transfered to the Leiden University Medical Center. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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AU - Oudijk, Martijn

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AU - Struys, Michel

AU - Willem Mol, Ben

AU - Van Lith, Jan

AU - Van Den Akker-Van Marle, Elske

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N2 - Objective To compare the costs of a strategy of patient controlled remifentanil versus epidural analgesia for pain relief in labour. Design We performed a multicentre randomised controlled trial in 15 hospitals in the Netherlands, The RAVEL trial. Costs were analysed from a health care perspective alongside the RAVEL trial. Population Pregnant women of intermediate to high risk beyond 32 weeks gestation who planned vaginal delivery. Methods Women were randomised before the onset of labour, to receive either patient controlled remifentanil or epidural analgesia when pain relief was requested during labour.

AB - Objective To compare the costs of a strategy of patient controlled remifentanil versus epidural analgesia for pain relief in labour. Design We performed a multicentre randomised controlled trial in 15 hospitals in the Netherlands, The RAVEL trial. Costs were analysed from a health care perspective alongside the RAVEL trial. Population Pregnant women of intermediate to high risk beyond 32 weeks gestation who planned vaginal delivery. Methods Women were randomised before the onset of labour, to receive either patient controlled remifentanil or epidural analgesia when pain relief was requested during labour.

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An economic analysis of patient controlled remifentanil and epidural analgesia as pain relief in labour (RAVEL trial): A randomised controlled trial.

Abstract

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