A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.
Tommasi, S., Zanato, C., Carabeo, R., Mangoni, A., Dall'Angelo, S., & Zanda, M. (2015). An Efficient Route to N-Monosubstituted Guanidino-Lactams. Synthesis, 47(19), 3067-3078. [ss-2015-n0113-op]. https://doi.org/10.1055/s-0034-1378845