An Efficient Route to N-Monosubstituted Guanidino-Lactams

Sara Tommasi*, Chiara Zanato, Rey Carabeo, Arduino Mangoni, Sergio Dall'Angelo, Matteo Zanda

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)
6 Downloads (Pure)

Abstract

A small library of guanidino-lactams were synthesized in four steps and good overall yields by following the routes: preparation of guanylating agents, synthesis of protected guanidino-acids, cyclization to fully protected guanidino-lactams, and deprotection to the target compounds. The guanidino-lactams were assayed as antimicrobials on E. coli showing no significant antibiotic activity.
Original languageEnglish
Article numberss-2015-n0113-op
Pages (from-to)3067-3078
Number of pages12
JournalSynthesis
Volume47
Issue number19
Early online date25 Jun 2015
DOIs
Publication statusPublished - Oct 2015

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Lactams
Cyclization
Antibiotics
Escherichia coli
Anti-Bacterial Agents
Acids

Keywords

  • guanidines
  • guanylation
  • lactams
  • cyclization
  • antimicrobials

Cite this

Tommasi, S., Zanato, C., Carabeo, R., Mangoni, A., Dall'Angelo, S., & Zanda, M. (2015). An Efficient Route to N-Monosubstituted Guanidino-Lactams. Synthesis, 47(19), 3067-3078. [ss-2015-n0113-op]. https://doi.org/10.1055/s-0034-1378845

An Efficient Route to N-Monosubstituted Guanidino-Lactams. / Tommasi, Sara; Zanato, Chiara; Carabeo, Rey; Mangoni, Arduino; Dall'Angelo, Sergio; Zanda, Matteo.

In: Synthesis, Vol. 47, No. 19, ss-2015-n0113-op, 10.2015, p. 3067-3078.

Research output: Contribution to journalArticle

Tommasi, S, Zanato, C, Carabeo, R, Mangoni, A, Dall'Angelo, S & Zanda, M 2015, 'An Efficient Route to N-Monosubstituted Guanidino-Lactams', Synthesis, vol. 47, no. 19, ss-2015-n0113-op, pp. 3067-3078. https://doi.org/10.1055/s-0034-1378845
Tommasi S, Zanato C, Carabeo R, Mangoni A, Dall'Angelo S, Zanda M. An Efficient Route to N-Monosubstituted Guanidino-Lactams. Synthesis. 2015 Oct;47(19):3067-3078. ss-2015-n0113-op. https://doi.org/10.1055/s-0034-1378845
Tommasi, Sara ; Zanato, Chiara ; Carabeo, Rey ; Mangoni, Arduino ; Dall'Angelo, Sergio ; Zanda, Matteo. / An Efficient Route to N-Monosubstituted Guanidino-Lactams. In: Synthesis. 2015 ; Vol. 47, No. 19. pp. 3067-3078.
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