An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz Frank Schweiger, Timothy Andrew Davies Smith, Andrew Welch, Christophe Plisson, Antony D. Gee, David O'Hagan

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39 Citations (Scopus)

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications
Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalChemical Communications
Volume46
Issue number1
Early online date10 Nov 2009
DOIs
Publication statusPublished - 2010

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    Onega, M., Domarkas, J., Deng, H., Schweiger, L. F., Smith, T. A. D., Welch, A., Plisson, C., Gee, A. D., & O'Hagan , D. (2010). An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. Chemical Communications, 46(1), 139-141. https://doi.org/10.1039/b919364b