An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz Frank Schweiger, Timothy Andrew Davies Smith, Andrew Welch, Christophe Plisson, Antony D. Gee, David O'Hagan

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38 Citations (Scopus)

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications
Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalChemical Communications
Volume46
Issue number1
Early online date10 Nov 2009
DOIs
Publication statusPublished - 2010

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