An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz Frank Schweiger, Timothy Andrew Davies Smith, Andrew Welch, Christophe Plisson, Antony D. Gee, David O'Hagan

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications
Original languageEnglish
Pages (from-to)139-141
Number of pages3
JournalChemical Communications
Volume46
Issue number1
Early online date10 Nov 2009
DOIs
Publication statusPublished - 2010

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Positron emission tomography
Ribose
Sugars
Enzymes
Imaging techniques
5-deoxy-5-(18F)fluororibose
fluorinase
Biotransformation

Cite this

An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. / Onega, Mayca; Domarkas, Juozas; Deng, Hai; Schweiger, Lutz Frank; Smith, Timothy Andrew Davies; Welch, Andrew; Plisson, Christophe ; Gee, Antony D.; O'Hagan , David.

In: Chemical Communications, Vol. 46, No. 1, 2010, p. 139-141.

Research output: Contribution to journalArticle

Onega, Mayca ; Domarkas, Juozas ; Deng, Hai ; Schweiger, Lutz Frank ; Smith, Timothy Andrew Davies ; Welch, Andrew ; Plisson, Christophe ; Gee, Antony D. ; O'Hagan , David. / An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging. In: Chemical Communications. 2010 ; Vol. 46, No. 1. pp. 139-141.
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