An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega; Juozas Domarkas; Hai Deng; Lutz Frank Schweiger; Timothy Andrew Davies Smith; Andrew Welch; Christophe  Plisson; Antony D. Gee; David O'Hagan

doi:10.1039/b919364b

An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging

Mayca Onega, Juozas Domarkas, Hai Deng, Lutz Frank Schweiger, Timothy Andrew Davies Smith, Andrew Welch, Christophe Plisson, Antony D. Gee, David O'Hagan

University of St Andrews

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	1
Early online date	10 Nov 2009
DOIs	https://doi.org/10.1039/b919364b
Publication status	Published - 2010

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title = "An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging",

abstract = "An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications",

author = "Mayca Onega and Juozas Domarkas and Hai Deng and Schweiger, {Lutz Frank} and Smith, {Timothy Andrew Davies} and Andrew Welch and Christophe Plisson and Gee, {Antony D.} and David O'Hagan",

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doi = "10.1039/b919364b",

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AU - Onega, Mayca

AU - Domarkas, Juozas

AU - Deng, Hai

AU - Schweiger, Lutz Frank

AU - Smith, Timothy Andrew Davies

AU - Welch, Andrew

AU - Plisson, Christophe

AU - Gee, Antony D.

AU - O'Hagan , David

PY - 2010

Y1 - 2010

N2 - An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications

AB - An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[18F]fluororibose, a novel [18F]-fluorinated sugar suitable for positron emission tomography (PET) applications

U2 - 10.1039/b919364b

DO - 10.1039/b919364b

M3 - Article

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SN - 1359-7345

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SP - 139

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JO - Chemical Communications

JF - Chemical Communications

IS - 1

ER -

An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Abstract

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An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging