An enzymatic route to selenazolines

Jesko Koehnke, Falk Morawitz, Andrew F Bent, Wael E Houssen, Sally L Shirran, Matthew A Fuszard, Iain A Smellie, Catherine H Botting, Margaret C M Smith, Marcel Jaspars, James H Naismith

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalChemBioChem
Volume14
Issue number5
Early online date18 Feb 2013
DOIs
Publication statusPublished - 18 Mar 2013

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Selenocysteine
Pharmaceutical Chemistry
Poisons
Threonine
Serine
Cysteine
Enzymes

Keywords

  • biochemistry
  • biosynthesis
  • patellamides
  • selenazolines

Cite this

Koehnke, J., Morawitz, F., Bent, A. F., Houssen, W. E., Shirran, S. L., Fuszard, M. A., ... Naismith, J. H. (2013). An enzymatic route to selenazolines. ChemBioChem, 14(5), 564-567. https://doi.org/10.1002/cbic.201300037

An enzymatic route to selenazolines. / Koehnke, Jesko; Morawitz, Falk; Bent, Andrew F; Houssen, Wael E; Shirran, Sally L; Fuszard, Matthew A; Smellie, Iain A; Botting, Catherine H; Smith, Margaret C M; Jaspars, Marcel; Naismith, James H.

In: ChemBioChem, Vol. 14, No. 5, 18.03.2013, p. 564-567.

Research output: Contribution to journalArticle

Koehnke, J, Morawitz, F, Bent, AF, Houssen, WE, Shirran, SL, Fuszard, MA, Smellie, IA, Botting, CH, Smith, MCM, Jaspars, M & Naismith, JH 2013, 'An enzymatic route to selenazolines' ChemBioChem, vol. 14, no. 5, pp. 564-567. https://doi.org/10.1002/cbic.201300037
Koehnke J, Morawitz F, Bent AF, Houssen WE, Shirran SL, Fuszard MA et al. An enzymatic route to selenazolines. ChemBioChem. 2013 Mar 18;14(5):564-567. https://doi.org/10.1002/cbic.201300037
Koehnke, Jesko ; Morawitz, Falk ; Bent, Andrew F ; Houssen, Wael E ; Shirran, Sally L ; Fuszard, Matthew A ; Smellie, Iain A ; Botting, Catherine H ; Smith, Margaret C M ; Jaspars, Marcel ; Naismith, James H. / An enzymatic route to selenazolines. In: ChemBioChem. 2013 ; Vol. 14, No. 5. pp. 564-567.
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