An enzymatic route to selenazolines

Jesko Koehnke, Falk Morawitz, Andrew F Bent, Wael E Houssen, Sally L Shirran, Matthew A Fuszard, Iain A Smellie, Catherine H Botting, Margaret C M Smith, Marcel Jaspars, James H Naismith

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Ringing the changes: Selenazolines have applications in medicinal chemistry, but their synthesis is challenging. We report a new convenient and less toxic route to these heterocycles that starts from commercially available selenocysteine. The new route depends on a heterocyclase enzyme that creates oxazolines and thiazolines from serines/threonines and cysteines.
Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalChemBioChem
Volume14
Issue number5
Early online date18 Feb 2013
DOIs
Publication statusPublished - 18 Mar 2013

Keywords

  • biochemistry
  • biosynthesis
  • patellamides
  • selenazolines

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