Abstract
The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.
Original language | English |
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Pages (from-to) | 979-985 |
Number of pages | 7 |
Journal | Metallomics |
Volume | 7 |
Issue number | 6 |
Early online date | 26 Jan 2015 |
DOIs | |
Publication status | Published - Jun 2015 |