An evolutionary perspective on zinc uptake by human fungal pathogens

Duncan Wilson

Research output: Contribution to journalArticle

23 Citations (Scopus)
5 Downloads (Pure)

Abstract

The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.
Original languageEnglish
Pages (from-to)979-985
Number of pages7
JournalMetallomics
Volume7
Issue number6
Early online date26 Jan 2015
DOIs
Publication statusPublished - Jun 2015

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