An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.

Anthony R Butler, Robert A. Field, Iain Robert Greig, Frederick W Flitney, Stuart K Bisland, Faisal Khan, Jill J F Belch

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
Original languageEnglish
Pages (from-to)211-217
Number of pages7
JournalNitric Oxide: Biology and Chemistry
Volume1
Issue number3
DOIs
Publication statusPublished - Jun 1997

Fingerprint Dive into the research topics of 'An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.'. Together they form a unique fingerprint.

  • Cite this

    Butler, A. R., Field, R. A., Greig, I. R., Flitney, F. W., Bisland, S. K., Khan, F., & Belch, J. J. F. (1997). An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators. Nitric Oxide: Biology and Chemistry, 1(3), 211-217. https://doi.org/10.1006/niox.1997.0125