TY - JOUR
T1 - An examination of some derivatives of S-nitroso-1-thiosugars as vasodilators.
AU - Butler, Anthony R
AU - Field, Robert A.
AU - Greig, Iain Robert
AU - Flitney, Frederick W
AU - Bisland, Stuart K
AU - Khan, Faisal
AU - Belch, Jill J F
N1 - Acknowledgements
The scanning Doppler laser imager was purchased with a grant from Tenovus. The Arthritis & Rheumatism Council and the Rollo Trust contributed to the cost of consumables
PY - 1997/6
Y1 - 1997/6
N2 - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
AB - A number of S-nitrosated compounds derived from 1-thiosugars (glucose, galactose, xylose, maltose, and lactose) have been prepared and characterized. Most of the compounds obtained were unstable either as solids or in solution. However, S-nitroso-1-thio-2,3,4,6-tetra-O-acetylglucopyranose was stable enough to examine as a vasodilator using an isolated rat tail artery model. It also proved effective in human cutaneous vascular smooth muscle relaxation when delivered transdermally.
UR - https://doi.org/10.1006/niox.1997.0125
U2 - 10.1006/niox.1997.0125
DO - 10.1006/niox.1997.0125
M3 - Article
C2 - 9704582
VL - 1
SP - 211
EP - 217
JO - Nitric Oxide: Biology and Chemistry
JF - Nitric Oxide: Biology and Chemistry
SN - 1089-8603
IS - 3
ER -