An excess of widespread pain among South Asians: are low levels of vitamin D implicated?

Gary John MacFarlane, B. Palmer, D. Roy, C. Afzal, A. J. Silman, T. O'Neill

Research output: Contribution to journalEditorial

53 Citations (Scopus)

Abstract

Background: Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain.

Objective: To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D.

Methods: Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England.

Results: The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95% Cl 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians ( OR = 1.8, 95% Cl 0.7 to 4.7) and found that low levels of 25-OH vitamin D (< 10 ng/ml) were more common among those with widespread pain ( OR = 3.5, 95% Cl 0.4 to 31.0).

Conclusions: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.

Original languageEnglish
Pages (from-to)1217-1219
Number of pages2
JournalAnnals of the Rheumatic Diseases
Volume64
DOIs
Publication statusPublished - 2005

Keywords

  • MUSCULOSKELETAL PAIN
  • D DEFICIENCY
  • OSTEOMALACIA
  • PREVALENCE
  • BRITAIN
  • RISK

Cite this

An excess of widespread pain among South Asians: are low levels of vitamin D implicated? / MacFarlane, Gary John; Palmer, B.; Roy, D.; Afzal, C.; Silman, A. J.; O'Neill, T.

In: Annals of the Rheumatic Diseases, Vol. 64, 2005, p. 1217-1219.

Research output: Contribution to journalEditorial

MacFarlane, Gary John ; Palmer, B. ; Roy, D. ; Afzal, C. ; Silman, A. J. ; O'Neill, T. / An excess of widespread pain among South Asians: are low levels of vitamin D implicated?. In: Annals of the Rheumatic Diseases. 2005 ; Vol. 64. pp. 1217-1219.
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abstract = "Background: Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain.Objective: To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D.Methods: Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England.Results: The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95{\%} Cl 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians ( OR = 1.8, 95{\%} Cl 0.7 to 4.7) and found that low levels of 25-OH vitamin D (< 10 ng/ml) were more common among those with widespread pain ( OR = 3.5, 95{\%} Cl 0.4 to 31.0).Conclusions: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.",
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author = "MacFarlane, {Gary John} and B. Palmer and D. Roy and C. Afzal and Silman, {A. J.} and T. O'Neill",
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TY - JOUR

T1 - An excess of widespread pain among South Asians: are low levels of vitamin D implicated?

AU - MacFarlane, Gary John

AU - Palmer, B.

AU - Roy, D.

AU - Afzal, C.

AU - Silman, A. J.

AU - O'Neill, T.

PY - 2005

Y1 - 2005

N2 - Background: Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain.Objective: To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D.Methods: Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England.Results: The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95% Cl 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians ( OR = 1.8, 95% Cl 0.7 to 4.7) and found that low levels of 25-OH vitamin D (< 10 ng/ml) were more common among those with widespread pain ( OR = 3.5, 95% Cl 0.4 to 31.0).Conclusions: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.

AB - Background: Anecdotal reports from rheumatologists in the United Kingdom suggest that patients from South Asian backgrounds are more likely to report widespread body pain.Objective: To confirm the presence of an excess of widespread pain in South Asians, and to evaluate the relationship of their symptoms with levels of 25-OH vitamin D.Methods: Two population studies involving over 3135 subjects were carried out in the North West and Midlands areas of England.Results: The first study confirmed an excess of widespread pain among South Asians (OR = 1.6, 95% Cl 1.3 to 2.1). The second smaller study conducted only among young women also showed a similar excess of widespread pain among South Asians ( OR = 1.8, 95% Cl 0.7 to 4.7) and found that low levels of 25-OH vitamin D (< 10 ng/ml) were more common among those with widespread pain ( OR = 3.5, 95% Cl 0.4 to 31.0).Conclusions: Owing to the small numbers, the relationship between 25-OH vitamin D and widespread pain must be considered preliminary and requires further investigation. However, it may be one potentially treatable cause of widespread pain.

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KW - OSTEOMALACIA

KW - PREVALENCE

KW - BRITAIN

KW - RISK

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DO - 10.1136/ard.2004.032656

M3 - Editorial

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JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

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