TY - JOUR
T1 - An imbalance in serum concentrations of inflammatory and anti-inflammatory cytokines in hypertension
AU - Mirhafeza, Seyed Reza
AU - Mohebati, Mohsen
AU - Disfani, Mahboobeh Feiz
AU - Karimian, Maryam Saberi
AU - Ebrahimi, Mahmoud
AU - Avan, Amir
AU - Eslami, Saied
AU - Pasdar, Alireza
AU - Rooki, Hassan
AU - Esmaeili, Habibollah
AU - Ferns, Gordon A.
AU - Ghayour-Mobarhan, Majid
N1 - Funding: This work was supported by Research Project No. 910823, as a PhD thesis, financed by the cardiovascular research center, Mashhad University of Medical Sciences.
PY - 2014
Y1 - 2014
N2 - Hypertension is an important risk factor for cardiovascular disease and there is increasing evidence that inflammation and abnormal immune responses are involved in the pathogenesis of hypertension. However, the data on the association between specific cytokine concentrations and hypertension are inconsistent. We have evaluated the association between 12 cytokines/growth factors and the presence of different degrees of hypertension, comparing these concentrations to values in a healthy group of subjects. The concentrations of interleukin (IL)-1α,-1β,-2,-4,-6,-8,-10, tumor necrosis factor (TNF-α), interferong (IFN-γ), monocyte chemoattractant protein (MCP-1), epidermal growth factor, and vascular endothelial growth factor were measured in 155 hypertensive patients and 148 healthy subjects, using EV-3513 cytokine biochip arrays, a competitive chemiluminescence immunoassay. Univariate and multivariate analyses were used to evaluate the association of specific cytokines and growth factors with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertensive subjects had higher serum concentrations of IL-1α,-2,-8, vascular endothelial growth factor, IFN-γ, TNF-α, MCP-1, and epidermal growth factor; and lower concentrations of anti-inflammatory cytokine, IL-10 (P <.05), compared with the healthy individuals. The serum concentrations of IL-4,-6, and-1b did not differ between the hypertensive subjects and control group. Univariate and multivariate analyses revealed that IL-1a and IFN-γ were independent predictors of a high SBP, while IFN-γ, IL-1α, TNF-α, and MCP-1 remained statistically significant for DBP after correction for age, gender, Body mass index, smoking, fasting blood glucose, and triglycerides. There was a significant association between the concentrations of several cytokines and hypertension. These associations may either be related to common underlying factors that cause hypertension and may also be proinflammatory or because these inflammatory cytokines might directly be involved in the etiology of hypertension.
AB - Hypertension is an important risk factor for cardiovascular disease and there is increasing evidence that inflammation and abnormal immune responses are involved in the pathogenesis of hypertension. However, the data on the association between specific cytokine concentrations and hypertension are inconsistent. We have evaluated the association between 12 cytokines/growth factors and the presence of different degrees of hypertension, comparing these concentrations to values in a healthy group of subjects. The concentrations of interleukin (IL)-1α,-1β,-2,-4,-6,-8,-10, tumor necrosis factor (TNF-α), interferong (IFN-γ), monocyte chemoattractant protein (MCP-1), epidermal growth factor, and vascular endothelial growth factor were measured in 155 hypertensive patients and 148 healthy subjects, using EV-3513 cytokine biochip arrays, a competitive chemiluminescence immunoassay. Univariate and multivariate analyses were used to evaluate the association of specific cytokines and growth factors with systolic blood pressure (SBP) and diastolic blood pressure (DBP). Hypertensive subjects had higher serum concentrations of IL-1α,-2,-8, vascular endothelial growth factor, IFN-γ, TNF-α, MCP-1, and epidermal growth factor; and lower concentrations of anti-inflammatory cytokine, IL-10 (P <.05), compared with the healthy individuals. The serum concentrations of IL-4,-6, and-1b did not differ between the hypertensive subjects and control group. Univariate and multivariate analyses revealed that IL-1a and IFN-γ were independent predictors of a high SBP, while IFN-γ, IL-1α, TNF-α, and MCP-1 remained statistically significant for DBP after correction for age, gender, Body mass index, smoking, fasting blood glucose, and triglycerides. There was a significant association between the concentrations of several cytokines and hypertension. These associations may either be related to common underlying factors that cause hypertension and may also be proinflammatory or because these inflammatory cytokines might directly be involved in the etiology of hypertension.
KW - Blood pressure
KW - Growth factors
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=84922194135&partnerID=8YFLogxK
U2 - 10.1016/j.jash.2014.05.007
DO - 10.1016/j.jash.2014.05.007
M3 - Article
C2 - 25224864
AN - SCOPUS:84922194135
SN - 1933-1711
VL - 8
SP - 614
EP - 623
JO - Journal of the American Society of Hypertension
JF - Journal of the American Society of Hypertension
IS - 9
ER -
