An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this paper, a qualitative model learning (QML) system is proposed to qualitatively reconstruct the detoxification pathway of Methylglyoxal. First a converting algorithm is implemented to convert possible pathways to qualitative models. Then a general learning strategy is presented. To improve the scalability of the proposed QML system and make it adapt to future more complicated pathways, an immune-inspired approach, a modified clonal selection algorithm, is proposed. The performance of this immune-inspired approach is compared with those of exhaustive search and two backtracking algorithms. The experimental results indicate that this approach can significantly improve the search efficiency when dealing with some complicated pathways with large-scale search spaces.
Original languageEnglish
Title of host publicationLecture Notes in Computer Science
PublisherSpringer
Pages151-164
Number of pages14
Volume5666
ISBN (Print)978-3-642-03245-5
DOIs
Publication statusPublished - 28 Jul 2009

Publication series

NameLecture Notes in Computer Science
PublisherSpringer
Volume5666
ISSN (Print)0302-9743

Fingerprint

Detoxification
Identification (control systems)
Learning systems
Scalability

Cite this

Pang, W., & Coghill, G. M. (2009). An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal. In Lecture Notes in Computer Science (Vol. 5666, pp. 151-164). (Lecture Notes in Computer Science; Vol. 5666). Springer . https://doi.org/10.1007/978-3-642-03246-2_17

An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal. / Pang, Wei; Coghill, George M.

Lecture Notes in Computer Science. Vol. 5666 Springer , 2009. p. 151-164 (Lecture Notes in Computer Science; Vol. 5666).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pang, W & Coghill, GM 2009, An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal. in Lecture Notes in Computer Science. vol. 5666, Lecture Notes in Computer Science, vol. 5666, Springer , pp. 151-164. https://doi.org/10.1007/978-3-642-03246-2_17
Pang W, Coghill GM. An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal. In Lecture Notes in Computer Science. Vol. 5666. Springer . 2009. p. 151-164. (Lecture Notes in Computer Science). https://doi.org/10.1007/978-3-642-03246-2_17
Pang, Wei ; Coghill, George M. / An Immune-Inspired Approach to Qualitative System Identification of the Detoxification Pathway of Methylglyoxal. Lecture Notes in Computer Science. Vol. 5666 Springer , 2009. pp. 151-164 (Lecture Notes in Computer Science).
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