An integrated model of the recognition of Candida albicans by the innate immune system

Mihai G. Netea, Gordon D. Brown, Bart Jan Kullberg, Neil A. R. Gow

Research output: Contribution to journalLiterature review

584 Citations (Scopus)

Abstract

The innate immune response was once considered to be a limited set of responses that aimed to contain an infection by primitive 'ingest and kill' mechanisms, giving the host time to mount a specific humoral and cellular immune response. In the mid-1990s, however, the discovery of Toll-like receptors heralded a revolution in our understanding of how microorganisms are recognized by the innate immune system, and how this system is activated. Several major classes of pathogen-recognition receptors have now been described, each with specific abilities to recognize conserved bacterial structures. The challenge ahead is to understand the level of complexity that underlies the response that is triggered by pathogen recognition. In this Review, we use the fungal pathogen Candida albicans as a model for the complex interaction that exists between the host pattern-recognition systems and invading microbial pathogens.

Original languageEnglish
Pages (from-to)67-78
Number of pages12
JournalNature Reviews Microbiology
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • toll-like receptor-2
  • macrophage mannose receptor
  • tumor-necrosis-factor
  • C-type lectin
  • blood-stream infections
  • adapter protein card9
  • beta-glucan receptor
  • regulatory T-cells
  • dendritic cells
  • host-defense

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