An international study of the quality of life of adult patients treated with home parenteral nutrition

Janet P Baxter; Peter M Fayers; Federico Bozzetti; Darlene Kelly; Francisca Joly; Geert Wanten; Cora Jonkers; Cristina Cuerda; Andre Van Gossum; Stanislaw Klek; Marie-France Boudreault; Alain Gilbert; Manon Jobin; Michael Staun; Lyn Gillanders; Alastair Forbes; Margie O'Callaghan; Ceferino Martinez Faedo; Cinzia Brunelli; Luigi Mariani; Loris Pironi

doi:10.1016/j.clnu.2018.07.024

An international study of the quality of life of adult patients treated with home parenteral nutrition

Janet P Baxter (Corresponding Author), Peter M Fayers, Federico Bozzetti, Darlene Kelly, Francisca Joly, Geert Wanten, Cora Jonkers, Cristina Cuerda, Andre Van Gossum, Stanislaw Klek, Marie-France Boudreault, Alain Gilbert, Manon Jobin, Michael Staun, Lyn Gillanders, Alastair Forbes, Margie O'Callaghan, Ceferino Martinez Faedo, Cinzia Brunelli, Luigi MarianiLoris Pironi

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Background & aims: Home parenteral nutrition-quality of life (HPN-QOL©) is a self-assessment tool for the measurement of QOL in patients on HPN. The aims of this study were: to re-assess the basic psychometric properties of the HPN-QOL© in a multinational sample of adult patients; to provide a description of QOL dimensions by short and long HPN treatment duration; to explore clinical factors potentially associated to QOL scores. Methods: Patients (n ¼ 699) from 14 countries completed the HPN-QOL©. The questionnaires were analysed to evaluate data completeness, convergent/discriminant validity and internal-consistency reliability. The association of overall QOL and HPN treatment duration as well as other clinical factors were investigated using multivariable linear regression models. Results: The analysis of the multitrait-scaling and internal consistency indicates a good fit with the questionnaire structure for most items. Item discriminant validity correlation was satisfactory and psychometric evaluation of the HPN-QOL© in the different English, French and Italian language patient sub-groups confirmed psychometric equivalence of the three questionnaire versions. The results of the multivariable linear regression showed that QOL scores were significantly associated with HPN duration (better in long-term), underlying disease (better in Crohn's disease and mesenteric ischaemia) and living status (worse in living alone) and, after adjusting for the other factors, with the number of days of HPN infusion per week. Conclusions: The HPN-QOL©, is a valid tool for measurement of QOL in patients on HPN, to be used in the clinical practice as well as in research

Original language	English
Pages (from-to)	1788-1796
Number of pages	9
Journal	Clinical Nutrition
Volume	38
Issue number	4
Early online date	6 Aug 2018
DOIs	https://doi.org/10.1016/j.clnu.2018.07.024
Publication status	Published - Aug 2019

Keywords

Home parenteral nutrition
Quality of life
Patient reported outcomes
Intestinal failure
SURVIVAL
IMPACT
FOLLOW-UP
CHRONIC INTESTINAL FAILURE

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Baxter, J. P., Fayers, P. M., Bozzetti, F., Kelly, D., Joly, F., Wanten, G., Jonkers, C., Cuerda, C., Van Gossum, A., Klek, S., Boudreault, M-F., Gilbert, A., Jobin, M., Staun, M., Gillanders, L., Forbes, A., O'Callaghan, M., Martinez Faedo, C., Brunelli, C., ... Pironi, L. (2019). An international study of the quality of life of adult patients treated with home parenteral nutrition. Clinical Nutrition, 38(4), 1788-1796. https://doi.org/10.1016/j.clnu.2018.07.024

Baxter, JP, Fayers, PM, Bozzetti, F, Kelly, D, Joly, F, Wanten, G, Jonkers, C, Cuerda, C, Van Gossum, A, Klek, S, Boudreault, M-F, Gilbert, A, Jobin, M, Staun, M, Gillanders, L, Forbes, A, O'Callaghan, M, Martinez Faedo, C, Brunelli, C, Mariani, L & Pironi, L 2019, 'An international study of the quality of life of adult patients treated with home parenteral nutrition', Clinical Nutrition, vol. 38, no. 4, pp. 1788-1796. https://doi.org/10.1016/j.clnu.2018.07.024

@article{26ecf13b70dc4a71b5220d5723a2d8d7,

title = "An international study of the quality of life of adult patients treated with home parenteral nutrition",

abstract = "Background & aims: Home parenteral nutrition-quality of life (HPN-QOL{\textcopyright}) is a self-assessment tool for the measurement of QOL in patients on HPN. The aims of this study were: to re-assess the basic psychometric properties of the HPN-QOL{\textcopyright} in a multinational sample of adult patients; to provide a description of QOL dimensions by short and long HPN treatment duration; to explore clinical factors potentially associated to QOL scores. Methods: Patients (n ¼ 699) from 14 countries completed the HPN-QOL{\textcopyright}. The questionnaires were analysed to evaluate data completeness, convergent/discriminant validity and internal-consistency reliability. The association of overall QOL and HPN treatment duration as well as other clinical factors were investigated using multivariable linear regression models. Results: The analysis of the multitrait-scaling and internal consistency indicates a good fit with the questionnaire structure for most items. Item discriminant validity correlation was satisfactory and psychometric evaluation of the HPN-QOL{\textcopyright} in the different English, French and Italian language patient sub-groups confirmed psychometric equivalence of the three questionnaire versions. The results of the multivariable linear regression showed that QOL scores were significantly associated with HPN duration (better in long-term), underlying disease (better in Crohn's disease and mesenteric ischaemia) and living status (worse in living alone) and, after adjusting for the other factors, with the number of days of HPN infusion per week. Conclusions: The HPN-QOL{\textcopyright}, is a valid tool for measurement of QOL in patients on HPN, to be used in the clinical practice as well as in research",

keywords = "Home parenteral nutrition, Quality of life, Patient reported outcomes, Intestinal failure, SURVIVAL, IMPACT, FOLLOW-UP, CHRONIC INTESTINAL FAILURE",

author = "Baxter, {Janet P} and Fayers, {Peter M} and Federico Bozzetti and Darlene Kelly and Francisca Joly and Geert Wanten and Cora Jonkers and Cristina Cuerda and {Van Gossum}, Andre and Stanislaw Klek and Marie-France Boudreault and Alain Gilbert and Manon Jobin and Michael Staun and Lyn Gillanders and Alastair Forbes and Margie O'Callaghan and {Martinez Faedo}, Ceferino and Cinzia Brunelli and Luigi Mariani and Loris Pironi",

note = "This study was funded by an ESPEN Research Network Grant 2009. ",

year = "2019",

month = aug,

doi = "10.1016/j.clnu.2018.07.024",

language = "English",

volume = "38",

pages = "1788--1796",

journal = "Clinical Nutrition",

issn = "0261-5614",

publisher = "Churchill Livingstone",

number = "4",

}

TY - JOUR

T1 - An international study of the quality of life of adult patients treated with home parenteral nutrition

AU - Baxter, Janet P

AU - Fayers, Peter M

AU - Bozzetti, Federico

AU - Kelly, Darlene

AU - Joly, Francisca

AU - Wanten, Geert

AU - Jonkers, Cora

AU - Cuerda, Cristina

AU - Van Gossum, Andre

AU - Klek, Stanislaw

AU - Boudreault, Marie-France

AU - Gilbert, Alain

AU - Jobin, Manon

AU - Staun, Michael

AU - Gillanders, Lyn

AU - Forbes, Alastair

AU - O'Callaghan, Margie

AU - Martinez Faedo, Ceferino

AU - Brunelli, Cinzia

AU - Mariani, Luigi

AU - Pironi, Loris

N1 - This study was funded by an ESPEN Research Network Grant 2009.

PY - 2019/8

Y1 - 2019/8

N2 - Background & aims: Home parenteral nutrition-quality of life (HPN-QOL©) is a self-assessment tool for the measurement of QOL in patients on HPN. The aims of this study were: to re-assess the basic psychometric properties of the HPN-QOL© in a multinational sample of adult patients; to provide a description of QOL dimensions by short and long HPN treatment duration; to explore clinical factors potentially associated to QOL scores. Methods: Patients (n ¼ 699) from 14 countries completed the HPN-QOL©. The questionnaires were analysed to evaluate data completeness, convergent/discriminant validity and internal-consistency reliability. The association of overall QOL and HPN treatment duration as well as other clinical factors were investigated using multivariable linear regression models. Results: The analysis of the multitrait-scaling and internal consistency indicates a good fit with the questionnaire structure for most items. Item discriminant validity correlation was satisfactory and psychometric evaluation of the HPN-QOL© in the different English, French and Italian language patient sub-groups confirmed psychometric equivalence of the three questionnaire versions. The results of the multivariable linear regression showed that QOL scores were significantly associated with HPN duration (better in long-term), underlying disease (better in Crohn's disease and mesenteric ischaemia) and living status (worse in living alone) and, after adjusting for the other factors, with the number of days of HPN infusion per week. Conclusions: The HPN-QOL©, is a valid tool for measurement of QOL in patients on HPN, to be used in the clinical practice as well as in research

AB - Background & aims: Home parenteral nutrition-quality of life (HPN-QOL©) is a self-assessment tool for the measurement of QOL in patients on HPN. The aims of this study were: to re-assess the basic psychometric properties of the HPN-QOL© in a multinational sample of adult patients; to provide a description of QOL dimensions by short and long HPN treatment duration; to explore clinical factors potentially associated to QOL scores. Methods: Patients (n ¼ 699) from 14 countries completed the HPN-QOL©. The questionnaires were analysed to evaluate data completeness, convergent/discriminant validity and internal-consistency reliability. The association of overall QOL and HPN treatment duration as well as other clinical factors were investigated using multivariable linear regression models. Results: The analysis of the multitrait-scaling and internal consistency indicates a good fit with the questionnaire structure for most items. Item discriminant validity correlation was satisfactory and psychometric evaluation of the HPN-QOL© in the different English, French and Italian language patient sub-groups confirmed psychometric equivalence of the three questionnaire versions. The results of the multivariable linear regression showed that QOL scores were significantly associated with HPN duration (better in long-term), underlying disease (better in Crohn's disease and mesenteric ischaemia) and living status (worse in living alone) and, after adjusting for the other factors, with the number of days of HPN infusion per week. Conclusions: The HPN-QOL©, is a valid tool for measurement of QOL in patients on HPN, to be used in the clinical practice as well as in research

KW - Home parenteral nutrition

KW - Quality of life

KW - Patient reported outcomes

KW - Intestinal failure

KW - SURVIVAL

KW - IMPACT

KW - FOLLOW-UP

KW - CHRONIC INTESTINAL FAILURE

UR - http://www.mendeley.com/research/international-study-quality-life-adult-patients-treated-home-parenteral-nutrition

U2 - 10.1016/j.clnu.2018.07.024

DO - 10.1016/j.clnu.2018.07.024

M3 - Article

VL - 38

SP - 1788

EP - 1796

JO - Clinical Nutrition

JF - Clinical Nutrition

SN - 0261-5614

IS - 4

ER -

An international study of the quality of life of adult patients treated with home parenteral nutrition

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Keywords

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