TY - JOUR
T1 - An Update on Preclinical Research in Anesthetic-Induced Developmental Neurotoxicity in Nonhuman Primate and Rodent Models
AU - Neudecker, Viola
AU - Xu, Jing
AU - Thomas, Monica A.
AU - Penberthy, Kristen K.
AU - Kang, Eunchai
AU - Berg, Daniel A.
AU - Omeara, Alia M.I.
AU - Brambrink, Ansgar M.
AU - Mintz, Cyrus David
N1 - Funding Information:
Supported by NIH R01GM137213-01 to CDM.
PY - 2023/1/1
Y1 - 2023/1/1
N2 - The 2022 Pediatric Anesthesia and NeuroDevelopment Assessment (PANDA) Meeting included an update on preclinical research in the field of anesthetic-induced developmental neurotoxicity (AIDN), with a focus on key developments since last meeting 3 years prior. The focus was on two areas: (1) The rapid growth in reports from nonhuman primate (NHP) studies, which play a pivotal role in understanding what elements of AIDN are likely to translate to human patients; and (2) The exploration of new targets, phenotypes, and exposure paradigms that have been conducted in rodent models. The purpose of this commentary article is to summarize this discussion and expand upon it both to update the reader on key developments in AIDN research and to highlight the importance of continued animal model research.
AB - The 2022 Pediatric Anesthesia and NeuroDevelopment Assessment (PANDA) Meeting included an update on preclinical research in the field of anesthetic-induced developmental neurotoxicity (AIDN), with a focus on key developments since last meeting 3 years prior. The focus was on two areas: (1) The rapid growth in reports from nonhuman primate (NHP) studies, which play a pivotal role in understanding what elements of AIDN are likely to translate to human patients; and (2) The exploration of new targets, phenotypes, and exposure paradigms that have been conducted in rodent models. The purpose of this commentary article is to summarize this discussion and expand upon it both to update the reader on key developments in AIDN research and to highlight the importance of continued animal model research.
UR - http://www.scopus.com/inward/record.url?scp=85143641964&partnerID=8YFLogxK
U2 - 10.1097/ANA.0000000000000885
DO - 10.1097/ANA.0000000000000885
M3 - Conference article
AN - SCOPUS:85143641964
SN - 0898-4921
VL - 35
SP - 104
EP - 113
JO - Journal of Neurosurgical Anesthesiology
JF - Journal of Neurosurgical Anesthesiology
IS - 1
T2 - The Seventh PANDA (Pediatric Anesthesia & NeuroDevelopment Assessment) Symposium
Y2 - 19 February 2022 through 20 February 2022
ER -