S. aureus is equipped with microbial surface components recognizing adhesive matrix molecules (MSCRAMMS), which are well defined adhesion molecules on the bacterial surface, able to promote adherence to cardiac endothelial cells. S. aureus can multiply and persist within cardiac cells, further promoting vegetation growth via activation of cytokines and thrombotic pathways . Moreover in S. aureus -PVE, surface biofilm formation complicates eradication of the infection. S. aureus has been identified as an independent predictor of poor outcome in IE , . In this review an expert group from the International Society of Antimicrobial Chemotherapy (ISAC) will present recent data, evidence and personal experience on S. aureus IE.
- Staphylococcus aureus
- infective endocarditis
- prosthetic valve endocarditis
- Panton–Valentine leukocidin
- Infective endocarditis
- Prosthetic valve endocarditis