Analysis of finite dose dermal absorption data: implications for dermal exposure assessment

H Frederick Frasch; G Scott Dotson; Annette L Bunge; Chen-Peng Chen; John W Cherrie; Gerald B Kasting; John C Kissel; Jennifer Sahmel; Sean Semple; Simon Wilkinson

doi:10.1038/jes.2013.23

Analysis of finite dose dermal absorption data: implications for dermal exposure assessment

H Frederick Frasch, G Scott Dotson, Annette L Bunge, Chen-Peng Chen, John W Cherrie, Gerald B Kasting, John C Kissel, Jennifer Sahmel, Sean Semple, Simon Wilkinson

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Abstract

A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.Journal of Exposure Science and Environmental Epidemiology advance online publication, 29 May 2013; doi:10.1038/jes.2013.23.

Original language	English
Pages (from-to)	65-73
Number of pages	9
Journal	Journal of Exposure Science and Environmental Epidemiology
Volume	24
Issue number	1
Early online date	29 May 2013
DOIs	https://doi.org/10.1038/jes.2013.23
Publication status	Published - Jan 2014

Keywords

risk assessment
skin absorption
percent absorption
fractional absorption
dermal load
maximum flux
evaporation

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10.1038/jes.2013.23

analysis of final dose dermal
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title = "Analysis of finite dose dermal absorption data: implications for dermal exposure assessment",

abstract = "A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.Journal of Exposure Science and Environmental Epidemiology advance online publication, 29 May 2013; doi:10.1038/jes.2013.23.",

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AU - Frasch, H Frederick

AU - Dotson, G Scott

AU - Bunge, Annette L

AU - Chen, Chen-Peng

AU - Cherrie, John W

AU - Kasting, Gerald B

AU - Kissel, John C

AU - Sahmel, Jennifer

AU - Semple, Sean

AU - Wilkinson, Simon

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AB - A common dermal exposure assessment strategy estimates the systemic uptake of chemical in contact with skin using the fixed fractional absorption approach: the dermal absorbed dose is estimated as the product of exposure and the fraction of applied chemical that is absorbed, assumed constant for a given chemical. Despite the prominence of this approach there is little guidance regarding the evaluation of experiments from which fractional absorption data are measured. An analysis of these experiments is presented herein, and limitations to the fixed fractional absorption approach are discussed. The analysis provides a set of simple algebraic expressions that may be used in the evaluation of finite dose dermal absorption experiments, affording a more data-driven approach to dermal exposure assessment. Case studies are presented that demonstrate the application of these tools to the assessment of dermal absorption data.Journal of Exposure Science and Environmental Epidemiology advance online publication, 29 May 2013; doi:10.1038/jes.2013.23.

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KW - skin absorption

KW - percent absorption

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KW - dermal load

KW - maximum flux

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Analysis of finite dose dermal absorption data: implications for dermal exposure assessment

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Keywords

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