Analysis of trabecular bone structure using fourier transforms and neural networks

J. S. Gregory, P.E. Undrill, R.M. Aspden, R.M. Junold

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Hip fracture due to osteoporosis (OP) and hip osteoarthritis (OA) are both important causes of locomotor morbidity in the elderly population. In osteoporosis, bone mass gradually decreases until the skeleton is too fragile to support the body and a fracture occurs, typically in the femur, wrist, or spine. In osteoarthritis, there is a proliferation of bone, leading to a stiffening of the tissue. Current clinical methods for assessment of bone changes in these disorders largely depend on assessing bone mineral density. However, this does not provide any information about bone structure which is considered to be an equally important factor in assessing bone quality. This paper presents a novel approach for computer analysis of trabecular (or cancellous) bone structure. The technique uses a Fourier transform to generate a "spectral fingerprint" of an image. Principal components analysis is then applied to identify key features from the Fourier transform and this information passed to a neural network for classification. Testing this on a series of 100 histological sections of trabecular bone from patients with OP and OA and a normal group correctly classified over 90% of the OP group with an overall accuracy of 77%-84%. Such high success rates on a small group suggest that this may provide a simple, but powerful, method for identifying alterations in bone structure.
Original languageEnglish
Pages (from-to)289-294
Number of pages6
JournalIEEE Transactions on Information Technology in Biomedicine
Volume3
Issue number4
Publication statusPublished - 1 Jan 1999

Fingerprint

Fourier Analysis
Fourier transforms
Bone
Neural networks
Bone and Bones
Osteoporosis
Osteoarthritis
Hip Osteoarthritis
Hip Fractures
Dermatoglyphics
Principal Component Analysis
Wrist
Skeleton
Bone Density
Femur
Cancellous Bone
Spine
Morbidity
Principal component analysis
Minerals

Cite this

Analysis of trabecular bone structure using fourier transforms and neural networks. / Gregory, J. S.; Undrill, P.E.; Aspden, R.M.; Junold, R.M.

In: IEEE Transactions on Information Technology in Biomedicine, Vol. 3, No. 4, 01.01.1999, p. 289-294.

Research output: Contribution to journalArticle

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