Ancestral TSH mechanism signals summer in a photoperiodic mammal

Elodie A. Hanon, Gerald A. Lincoln, Jean-Michel Fustin, Hugues Dardente, Mireille Masson-Pevet, Peter J. Morgan, David G. Hazlerigg

Research output: Contribution to journalArticle

247 Citations (Scopus)

Abstract

In mammals, day-length-sensitive (photoperiodic) seasonal breeding cycles depend on the pineal hormone melatonin, which modulates secretion of reproductive hormones by the anterior pituitary gland [1]. It is thought that melatonin acts in the hypothalamus to control reproduction through the release of neurosecretory signals into the pituitary portal blood supply, where they act on pituitary endocrine cells [2]. Contrastingly, we show here that during the reproductive response of Soay sheep exposed to summer day lengths, the reverse applies: Melatonin acts directly on anterior-pituitary cells, and these then relay the photoperiodic message back into the hypothalamus to control neuroendocrine output. The switch to long clays causes melatonin-responsive cells in the pars tuberalis (PT) of the anterior pituitary to increase production of thyrotrophin (TSH). This acts locally on TSH-receptor-expressing cells in the adjacent mediobasal hypothalamus, leading to increased expression of type 11 thyroid hormone deiodinase (13102). DIO2 initiates the summer response by increasing hypothalamic tri-iodothyronine (T3) levels. These data and recent findings in quail [3] indicate that the TSH-expressing cells of the PT play an ancestral role in seasonal reproductive control in vertebrates. In mammals this provides the missing link between the pineal melatonin signal and thyroid-dependent seasonal biology.

Original languageEnglish
Pages (from-to)1147-1152
Number of pages6
JournalCurrent Biology
Volume18
Issue number15
DOIs
Publication statusPublished - 5 Aug 2008

Keywords

  • MT1 melatonin receptor
  • type-2 deiodinase gene
  • male Syrian-hamsters
  • pars tuberalis
  • mediobasal hypothalamus
  • binding-sites
  • preoptic area
  • body-weight
  • cyclic-amp
  • hormone

Cite this

Hanon, E. A., Lincoln, G. A., Fustin, J-M., Dardente, H., Masson-Pevet, M., Morgan, P. J., & Hazlerigg, D. G. (2008). Ancestral TSH mechanism signals summer in a photoperiodic mammal. Current Biology, 18(15), 1147-1152. https://doi.org/10.1016/j.cub.2008.06.076