The androgen receptor is a key regulator of physiological development in utero and tissue homeostasis in adult men and woman. The activity of the receptor is tightly regulated by the binding of the natural steroid hormone agonists, testosterone and dihydrotestosterone. Activation of the receptor leads to dimerization, nuclear translocation and activation of target genes. Clinically, synthetic agonists are used to treat conditions of hormone insufficiency. Conversely conditions arising from androgen excess or a dependence upon the androgen receptor can be treated with antagonists to blunt the response to natural hormones.
|Title of host publication||Encyclopedia of Reproduction|
|Number of pages||8|
|Publication status||Published - 30 Jul 2018|
- Androgenic steroids
- Ligand binding domain
- Prostate cancer