Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Judith E Allen; Robert J Bischof; Herng-Yu Sucie Chang; Jeremy A Hirota; Stuart J Hirst; Mark D Inman; Wayne Mitzner; Tara Sutherland

doi:10.1016/j.pupt.2009.04.001

Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Judith E Allen, Robert J Bischof, Herng-Yu Sucie Chang, Jeremy A Hirota, Stuart J Hirst, Mark D Inman, Wayne Mitzner, Tara Sutherland

Medical Sciences

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Asthma is a complex disease that involves chronic inflammation and subsequent decline in airway function. The widespread use of animal models has greatly contributed to our understanding of the cellular and molecular pathways underlying human allergic asthma. Animal models of allergic asthma include smaller animal models which offer 'ease of use' and availability of reagents, and larger animal models that may be used to address aspects of allergic airways disease not possible in humans or smaller animal models. This review examines the application and suitability of various animal models for studying mechanisms of airway inflammation and tissue remodelling in allergic asthma, with a specific focus on airway smooth muscle.

Original language	English
Pages (from-to)	455-465
Number of pages	11
Journal	Pharmacology & Therapeutics
Volume	22
Issue number	5
Early online date	23 Apr 2009
DOIs	https://doi.org/10.1016/j.pupt.2009.04.001
Publication status	Published - 1 Oct 2009

Bibliographical note

Acknowledgements
Judith Allen was supported by the Medical Research Council UK and Asthma UK. Robert Bischof was supported by the National Health and Medical Research Council (NHMRC) of Australia (310603) and Allergenix Pty Ltd. Herng-Yu Chang was supported by NIH grants HL-10342 and HL-07534. Jeremy Hirota was funded by a Canadian Lung Association/Canadian Thoracic Society Studentship. Jeremy Hirota and Mark Inman were also supported by the Canadian Institutes for Health Research (MOP-36328) and Astra-Zeneca. Stuart Hirst acknowledges the support of the NHMRC (566904) and Asthma UK (05/022, 05/027, 07/034). Wayne Mitzner was supported by NIH grants HL-10342 and HL-07534. Tara Sutherland was supported by Asthma UK. The authors would also like to thank Astra-Zeneca for sponsoring and the travel grants to attend the Sixth International Young Investigators' Symposium on Smooth Muscle in Sydney, Australia, November 2007.

Keywords

Animals
Asthma
Disease Models
Animal
Gonadal Steroid Hormones
Humans
Immune System
Inflammation
Inflammation Mediators
Muscle
Smooth
Respiratory System
Sex Characteristics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pupt.2009.04.001

Cite this

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abstract = "Asthma is a complex disease that involves chronic inflammation and subsequent decline in airway function. The widespread use of animal models has greatly contributed to our understanding of the cellular and molecular pathways underlying human allergic asthma. Animal models of allergic asthma include smaller animal models which offer 'ease of use' and availability of reagents, and larger animal models that may be used to address aspects of allergic airways disease not possible in humans or smaller animal models. This review examines the application and suitability of various animal models for studying mechanisms of airway inflammation and tissue remodelling in allergic asthma, with a specific focus on airway smooth muscle.",

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note = "Acknowledgements Judith Allen was supported by the Medical Research Council UK and Asthma UK. Robert Bischof was supported by the National Health and Medical Research Council (NHMRC) of Australia (310603) and Allergenix Pty Ltd. Herng-Yu Chang was supported by NIH grants HL-10342 and HL-07534. Jeremy Hirota was funded by a Canadian Lung Association/Canadian Thoracic Society Studentship. Jeremy Hirota and Mark Inman were also supported by the Canadian Institutes for Health Research (MOP-36328) and Astra-Zeneca. Stuart Hirst acknowledges the support of the NHMRC (566904) and Asthma UK (05/022, 05/027, 07/034). Wayne Mitzner was supported by NIH grants HL-10342 and HL-07534. Tara Sutherland was supported by Asthma UK. The authors would also like to thank Astra-Zeneca for sponsoring and the travel grants to attend the Sixth International Young Investigators' Symposium on Smooth Muscle in Sydney, Australia, November 2007.",

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Animal models of airway inflammation and airway smooth muscle remodelling in asthma

Abstract

Bibliographical note

Keywords

UN SDGs

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