Anomalous tissue vitamin E distribution in stress-susceptible pigs after dietary vitamin E supplementation and effects on plasma pyruvate kinase and creatine kinase activities

G. G. Duthie, J. R. Arthur, C. F. Mills, P. C. Morrice, F. Nicol

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Abstract

Halothane-reactor and non-reactor pigs were offered diets containing either 10 or 135 I.U. vitamin E kg−1 ad libitum for 6 weeks. There were no differences in food intake or weight gain between groups. The fat contents of the semi-tendinosus, gluteus medius and serratus muscles of reactors were significantly less than those of non-reactors irrespective of dietary vitamin E content. Vitamin E supplementation of diets significantly elevated plasma and tissue vitamin E concentrations of both reactors and non-reactors. However, after vitamin E supplementation, significantly higher vitamin E concentrations were found in muscles of reactors compared to non-reactors. A similar trend was apparent when the tissues of non-supplemented reactors and non-reactors were compared. There were no indications of antioxidant enzyme deficiencies in reactors. Plasma pyruvate kinase and creatine kinase activities did not discriminate between reactors and non-reactors. However, after application of a standard pharmacological stress (neostigmine bromide), plasma pyruvate kinase activities of reactors were higher than those of non-reactors irrespective of vitamin E supplementation of the diet. The possibility that vitamin E function is compromised in stress susceptible pigs, and that this may be compensated for by dietary vitamin E supplementation, is discussed.
Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalLivestock Production Science
Volume17
Issue number2
DOIs
Publication statusPublished - Sep 1987

Cite this

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title = "Anomalous tissue vitamin E distribution in stress-susceptible pigs after dietary vitamin E supplementation and effects on plasma pyruvate kinase and creatine kinase activities",
abstract = "Halothane-reactor and non-reactor pigs were offered diets containing either 10 or 135 I.U. vitamin E kg−1 ad libitum for 6 weeks. There were no differences in food intake or weight gain between groups. The fat contents of the semi-tendinosus, gluteus medius and serratus muscles of reactors were significantly less than those of non-reactors irrespective of dietary vitamin E content. Vitamin E supplementation of diets significantly elevated plasma and tissue vitamin E concentrations of both reactors and non-reactors. However, after vitamin E supplementation, significantly higher vitamin E concentrations were found in muscles of reactors compared to non-reactors. A similar trend was apparent when the tissues of non-supplemented reactors and non-reactors were compared. There were no indications of antioxidant enzyme deficiencies in reactors. Plasma pyruvate kinase and creatine kinase activities did not discriminate between reactors and non-reactors. However, after application of a standard pharmacological stress (neostigmine bromide), plasma pyruvate kinase activities of reactors were higher than those of non-reactors irrespective of vitamin E supplementation of the diet. The possibility that vitamin E function is compromised in stress susceptible pigs, and that this may be compensated for by dietary vitamin E supplementation, is discussed.",
author = "Duthie, {G. G.} and Arthur, {J. R.} and Mills, {C. F.} and Morrice, {P. C.} and F. Nicol",
year = "1987",
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T1 - Anomalous tissue vitamin E distribution in stress-susceptible pigs after dietary vitamin E supplementation and effects on plasma pyruvate kinase and creatine kinase activities

AU - Duthie, G. G.

AU - Arthur, J. R.

AU - Mills, C. F.

AU - Morrice, P. C.

AU - Nicol, F.

PY - 1987/9

Y1 - 1987/9

N2 - Halothane-reactor and non-reactor pigs were offered diets containing either 10 or 135 I.U. vitamin E kg−1 ad libitum for 6 weeks. There were no differences in food intake or weight gain between groups. The fat contents of the semi-tendinosus, gluteus medius and serratus muscles of reactors were significantly less than those of non-reactors irrespective of dietary vitamin E content. Vitamin E supplementation of diets significantly elevated plasma and tissue vitamin E concentrations of both reactors and non-reactors. However, after vitamin E supplementation, significantly higher vitamin E concentrations were found in muscles of reactors compared to non-reactors. A similar trend was apparent when the tissues of non-supplemented reactors and non-reactors were compared. There were no indications of antioxidant enzyme deficiencies in reactors. Plasma pyruvate kinase and creatine kinase activities did not discriminate between reactors and non-reactors. However, after application of a standard pharmacological stress (neostigmine bromide), plasma pyruvate kinase activities of reactors were higher than those of non-reactors irrespective of vitamin E supplementation of the diet. The possibility that vitamin E function is compromised in stress susceptible pigs, and that this may be compensated for by dietary vitamin E supplementation, is discussed.

AB - Halothane-reactor and non-reactor pigs were offered diets containing either 10 or 135 I.U. vitamin E kg−1 ad libitum for 6 weeks. There were no differences in food intake or weight gain between groups. The fat contents of the semi-tendinosus, gluteus medius and serratus muscles of reactors were significantly less than those of non-reactors irrespective of dietary vitamin E content. Vitamin E supplementation of diets significantly elevated plasma and tissue vitamin E concentrations of both reactors and non-reactors. However, after vitamin E supplementation, significantly higher vitamin E concentrations were found in muscles of reactors compared to non-reactors. A similar trend was apparent when the tissues of non-supplemented reactors and non-reactors were compared. There were no indications of antioxidant enzyme deficiencies in reactors. Plasma pyruvate kinase and creatine kinase activities did not discriminate between reactors and non-reactors. However, after application of a standard pharmacological stress (neostigmine bromide), plasma pyruvate kinase activities of reactors were higher than those of non-reactors irrespective of vitamin E supplementation of the diet. The possibility that vitamin E function is compromised in stress susceptible pigs, and that this may be compensated for by dietary vitamin E supplementation, is discussed.

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DO - 10.1016/0301-6226(87)90062-5

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