Antenatal factors in the development of the lumbar vertebral canal: a magnetic resonance imaging study

Janet Elizabeth Jeffrey, Doris Margaret Campbell, F. W. Smith, Michael Henry Niven Golden, R. W. Porter

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Study Design. The lumbar vertebral canal was measured, in two cohortsof 10-year-old children (n = 161) using magnetic resonance imaging (MRI) and compared with obstetric records.

Objective. To investigate whether there are identifiable obstetric factors that determine the size of the lumbar vertebral canal.

Summary of Background Data. The most rapids period vertebral canal is between 12 and 32 weeks in utero, with the midsagittal diameter of L1-L4 already 70% of adult dimension at birth. Therefore adverse antenatal factors during this critical growth period may be expected to affect the size of the canal.

Methods. The canal size was measured from axial MRI sections taken through each lumbar vertebra (L1-L5) at the pedicular level of 84 children. Relations with obstetric data, prospectively collected in a neonatal database, were of sought. The relation low birthweight and canal size was further investigated in a second cohort of children (n =77).

Results. The canal size, particularly the midsagittal diameter and the cross-sectional area was found to be significantly reduced by low birthweight (with growth retardation in utero being a more important factor than length of gestation), low placenta weight, and lower socioeconomic class. Smoking during pregnancy, significantly reduced the perimeter at L3 (P = 0.032) and L5 (P = 0.031), and also the cross-sectional area at L3 (P = 0.030) and L5 (P = 0.016).

Conclusions. This study showed that, for this group of children the size of the lumbar vertebral canal was reduced, by low birthweight, with maternal, smoking as an added adverse factor. Therefore, good antenatal care and maternal education may help to reduce the risk of spinal stenosis in adult life.

Original languageEnglish
Pages (from-to)1418-1423
Number of pages5
JournalSpine
Volume28
Issue number13
DOIs
Publication statusPublished - 1 Jul 2003

Keywords

  • child
  • development
  • magnetic resonance imaging
  • pregnancy
  • spinal canal
  • spinal stenosis
  • growth
  • morphometry
  • fetal

Cite this

Jeffrey, J. E., Campbell, D. M., Smith, F. W., Golden, M. H. N., & Porter, R. W. (2003). Antenatal factors in the development of the lumbar vertebral canal: a magnetic resonance imaging study. Spine, 28(13), 1418-1423. https://doi.org/10.1097/00007632-200307010-00012

Antenatal factors in the development of the lumbar vertebral canal : a magnetic resonance imaging study. / Jeffrey, Janet Elizabeth; Campbell, Doris Margaret; Smith, F. W.; Golden, Michael Henry Niven; Porter, R. W.

In: Spine, Vol. 28, No. 13, 01.07.2003, p. 1418-1423.

Research output: Contribution to journalArticle

Jeffrey, JE, Campbell, DM, Smith, FW, Golden, MHN & Porter, RW 2003, 'Antenatal factors in the development of the lumbar vertebral canal: a magnetic resonance imaging study', Spine, vol. 28, no. 13, pp. 1418-1423. https://doi.org/10.1097/00007632-200307010-00012
Jeffrey, Janet Elizabeth ; Campbell, Doris Margaret ; Smith, F. W. ; Golden, Michael Henry Niven ; Porter, R. W. / Antenatal factors in the development of the lumbar vertebral canal : a magnetic resonance imaging study. In: Spine. 2003 ; Vol. 28, No. 13. pp. 1418-1423.
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N2 - Study Design. The lumbar vertebral canal was measured, in two cohortsof 10-year-old children (n = 161) using magnetic resonance imaging (MRI) and compared with obstetric records.Objective. To investigate whether there are identifiable obstetric factors that determine the size of the lumbar vertebral canal.Summary of Background Data. The most rapids period vertebral canal is between 12 and 32 weeks in utero, with the midsagittal diameter of L1-L4 already 70% of adult dimension at birth. Therefore adverse antenatal factors during this critical growth period may be expected to affect the size of the canal.Methods. The canal size was measured from axial MRI sections taken through each lumbar vertebra (L1-L5) at the pedicular level of 84 children. Relations with obstetric data, prospectively collected in a neonatal database, were of sought. The relation low birthweight and canal size was further investigated in a second cohort of children (n =77).Results. The canal size, particularly the midsagittal diameter and the cross-sectional area was found to be significantly reduced by low birthweight (with growth retardation in utero being a more important factor than length of gestation), low placenta weight, and lower socioeconomic class. Smoking during pregnancy, significantly reduced the perimeter at L3 (P = 0.032) and L5 (P = 0.031), and also the cross-sectional area at L3 (P = 0.030) and L5 (P = 0.016).Conclusions. This study showed that, for this group of children the size of the lumbar vertebral canal was reduced, by low birthweight, with maternal, smoking as an added adverse factor. Therefore, good antenatal care and maternal education may help to reduce the risk of spinal stenosis in adult life.

AB - Study Design. The lumbar vertebral canal was measured, in two cohortsof 10-year-old children (n = 161) using magnetic resonance imaging (MRI) and compared with obstetric records.Objective. To investigate whether there are identifiable obstetric factors that determine the size of the lumbar vertebral canal.Summary of Background Data. The most rapids period vertebral canal is between 12 and 32 weeks in utero, with the midsagittal diameter of L1-L4 already 70% of adult dimension at birth. Therefore adverse antenatal factors during this critical growth period may be expected to affect the size of the canal.Methods. The canal size was measured from axial MRI sections taken through each lumbar vertebra (L1-L5) at the pedicular level of 84 children. Relations with obstetric data, prospectively collected in a neonatal database, were of sought. The relation low birthweight and canal size was further investigated in a second cohort of children (n =77).Results. The canal size, particularly the midsagittal diameter and the cross-sectional area was found to be significantly reduced by low birthweight (with growth retardation in utero being a more important factor than length of gestation), low placenta weight, and lower socioeconomic class. Smoking during pregnancy, significantly reduced the perimeter at L3 (P = 0.032) and L5 (P = 0.031), and also the cross-sectional area at L3 (P = 0.030) and L5 (P = 0.016).Conclusions. This study showed that, for this group of children the size of the lumbar vertebral canal was reduced, by low birthweight, with maternal, smoking as an added adverse factor. Therefore, good antenatal care and maternal education may help to reduce the risk of spinal stenosis in adult life.

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KW - magnetic resonance imaging

KW - pregnancy

KW - spinal canal

KW - spinal stenosis

KW - growth

KW - morphometry

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JO - Spine

JF - Spine

SN - 0362-2436

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