Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Mahasin Alnajjar, Sisir Kumar Barik, Charles Bestwick, Fiona Campbell, Morven Cruickshank, Freda Farquharson, Grietje Holtrop, Graham Horgan, Petra Louis, Kim-Marie Moar, Wendy R. Russell, Lorraine Scobbie, Nigel Hoggard* (Corresponding Author)

*Corresponding author for this work

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Abstract

This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.
Original languageEnglish
Article number103597
JournalJournal of Functional Foods
Volume64
Early online date31 Oct 2019
DOIs
Publication statusPublished - Jan 2020

Fingerprint

Vaccinium myrtillus
bilberries
Anthocyanins
volunteers
anthocyanins
Volunteers
insulin
Insulin
extracts
Glucose
glucose
placebos
Eating
Placebos
Postprandial Period
ingestion
Glucosidases
glucosidases
Microbiota
Apolipoprotein A-I

Keywords

  • Bilberry
  • Anthocyanins
  • Type 2 diabetes
  • Glycaemic response

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Medicine (miscellaneous)

Cite this

@article{a7858a613a914240ab054d872e72e69d,
title = "Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin",
abstract = "This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36{\%} (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20{\%}; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.",
keywords = "Bilberry, Anthocyanins, Type 2 diabetes, Glycaemic response",
author = "Mahasin Alnajjar and Barik, {Sisir Kumar} and Charles Bestwick and Fiona Campbell and Morven Cruickshank and Freda Farquharson and Grietje Holtrop and Graham Horgan and Petra Louis and Kim-Marie Moar and Russell, {Wendy R.} and Lorraine Scobbie and Nigel Hoggard",
note = "Acknowledgements We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) for funding. We thank staff in The Human Nutrition Unit at the University of Aberdeen, Rowett Institute for their assistance with the study, and Indena S.p.A. for supplying the Mirtoselect{\circledR} bilberry extract. We are grateful to the Kuwait government for additional funding. None of the authors had any conflicts of interest.",
year = "2020",
month = "1",
doi = "10.1016/j.jff.2019.103597",
language = "English",
volume = "64",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier",

}

TY - JOUR

T1 - Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

AU - Alnajjar, Mahasin

AU - Barik, Sisir Kumar

AU - Bestwick, Charles

AU - Campbell, Fiona

AU - Cruickshank, Morven

AU - Farquharson, Freda

AU - Holtrop, Grietje

AU - Horgan, Graham

AU - Louis, Petra

AU - Moar, Kim-Marie

AU - Russell, Wendy R.

AU - Scobbie, Lorraine

AU - Hoggard, Nigel

N1 - Acknowledgements We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) for funding. We thank staff in The Human Nutrition Unit at the University of Aberdeen, Rowett Institute for their assistance with the study, and Indena S.p.A. for supplying the Mirtoselect® bilberry extract. We are grateful to the Kuwait government for additional funding. None of the authors had any conflicts of interest.

PY - 2020/1

Y1 - 2020/1

N2 - This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.

AB - This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.

KW - Bilberry

KW - Anthocyanins

KW - Type 2 diabetes

KW - Glycaemic response

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DO - 10.1016/j.jff.2019.103597

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VL - 64

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

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