Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Mahasin Alnajjar; Sisir Kumar Barik; Charles Bestwick; Fiona Campbell; Morven Cruickshank; Freda Farquharson; Grietje Holtrop; Graham Horgan; Petra Louis; Kim-Marie Moar; Wendy R. Russell; Lorraine Scobbie; Nigel Hoggard

doi:10.1016/j.jff.2019.103597

Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Mahasin Alnajjar, Sisir Kumar Barik, Charles Bestwick, Fiona Campbell, Morven Cruickshank, Freda Farquharson, Grietje Holtrop, Graham Horgan, Petra Louis, Kim-Marie Moar, Wendy R. Russell, Lorraine Scobbie, Nigel Hoggard^* (Corresponding Author)

^*Corresponding author for this work

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Abstract

This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.

Original language	English
Article number	103597
Number of pages	12
Journal	Journal of Functional Foods
Volume	64
Early online date	31 Oct 2019
DOIs	https://doi.org/10.1016/j.jff.2019.103597
Publication status	Published - 1 Jan 2020

Keywords

Bilberry
Anthocyanins
Type 2 diabetes
Glycaemic response
ACID
PHENOLIC-COMPOUNDS
INHIBITORY-ACTIVITY
MICROBIOTA
POLYPHENOLS
OBESITY
PLASMA
DIVERSITY
GLUCOSE-UPTAKE
BERRY ANTHOCYANINS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Alnajjar_etal_JFuncFoods_Anthocyanin_enriched_VOR
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Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K-M., Russell, W. R., Scobbie, L., & Hoggard, N. (2020). Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin. Journal of Functional Foods, 64, [103597]. https://doi.org/10.1016/j.jff.2019.103597

Alnajjar, M, Barik, SK, Bestwick, C, Campbell, F, Cruickshank, M, Farquharson, F, Holtrop, G, Horgan, G , Louis, P, Moar, K-M, Russell, WR, Scobbie, L & Hoggard, N 2020, 'Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin', Journal of Functional Foods, vol. 64, 103597. https://doi.org/10.1016/j.jff.2019.103597

@article{a7858a613a914240ab054d872e72e69d,

title = "Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin",

abstract = "This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.",

keywords = "Bilberry, Anthocyanins, Type 2 diabetes, Glycaemic response, ACID, PHENOLIC-COMPOUNDS, INHIBITORY-ACTIVITY, MICROBIOTA, POLYPHENOLS, OBESITY, PLASMA, DIVERSITY, GLUCOSE-UPTAKE, BERRY ANTHOCYANINS",

author = "Mahasin Alnajjar and Barik, {Sisir Kumar} and Charles Bestwick and Fiona Campbell and Morven Cruickshank and Freda Farquharson and Grietje Holtrop and Graham Horgan and Petra Louis and Kim-Marie Moar and Russell, {Wendy R.} and Lorraine Scobbie and Nigel Hoggard",

note = "Acknowledgements We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) for funding. We thank staff in The Human Nutrition Unit at the University of Aberdeen, Rowett Institute for their assistance with the study, and Indena S.p.A. for supplying the Mirtoselect{\textregistered} bilberry extract. We are grateful to the Kuwait government for additional funding. None of the authors had any conflicts of interest.",

year = "2020",

month = jan,

day = "1",

doi = "10.1016/j.jff.2019.103597",

language = "English",

volume = "64",

journal = "Journal of Functional Foods",

issn = "1756-4646",

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TY - JOUR

T1 - Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

AU - Alnajjar, Mahasin

AU - Barik, Sisir Kumar

AU - Bestwick, Charles

AU - Campbell, Fiona

AU - Cruickshank, Morven

AU - Farquharson, Freda

AU - Holtrop, Grietje

AU - Horgan, Graham

AU - Louis, Petra

AU - Moar, Kim-Marie

AU - Russell, Wendy R.

AU - Scobbie, Lorraine

AU - Hoggard, Nigel

N1 - Acknowledgements We are grateful to the Scottish Government Rural and Environment Science and Analytical Services (RESAS) for funding. We thank staff in The Human Nutrition Unit at the University of Aberdeen, Rowett Institute for their assistance with the study, and Indena S.p.A. for supplying the Mirtoselect® bilberry extract. We are grateful to the Kuwait government for additional funding. None of the authors had any conflicts of interest.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.

AB - This study investigated the effect of a three week supplementation of bilberry extract on glucose metabolism. Overweight volunteers (n = 16; BMI 31) were given three capsules of either 0.47 g bilberry extract (36% (w/w) anthocyanins) or placebo per day for three weeks in a double blinded cross over intervention.The ingestion of the bilberry extract decreased the OGTT AUCi for glucose (20%; p = 0.008) but not for insulin compared with the placebo. There was no change in anti-inflammatory markers (hsCRP, MCP-1, leptin), vascular health markers (Apo A1, sVCAM-1, sICAM-1), reducing potential/ radical scavenging capacity or faecal bacterial microbiota. In vitro studies showed that the bilberry extract decreased α-amylase activity (p < 0.0001), α-glucosidase activity (p < 0.0001) and glucose uptake (p < 0.0001).This study demonstrates that the ingestion of a bilberry extract over a three week intervention period reduces postprandial glycaemia without changes in insulin. This is probably due to reduced rates of carbohydrate digestion and/or absorption.

KW - Bilberry

KW - Anthocyanins

KW - Type 2 diabetes

KW - Glycaemic response

KW - ACID

KW - PHENOLIC-COMPOUNDS

KW - INHIBITORY-ACTIVITY

KW - MICROBIOTA

KW - POLYPHENOLS

KW - OBESITY

KW - PLASMA

KW - DIVERSITY

KW - GLUCOSE-UPTAKE

KW - BERRY ANTHOCYANINS

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U2 - 10.1016/j.jff.2019.103597

DO - 10.1016/j.jff.2019.103597

M3 - Article

VL - 64

JO - Journal of Functional Foods

JF - Journal of Functional Foods

SN - 1756-4646

M1 - 103597

ER -

Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

Abstract

Keywords

UN SDGs

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