Antibiotics from Deep-Sea Microorganisms

Current Discoveries and Perspectives

Emiliana Tortorella, Pietro Tedesco, Fortunato Palma Esposito, Grant Garren January, Renato Fani, Marcel Jaspars, Donatella de Pascale (Corresponding Author)

Research output: Contribution to journalReview article

10 Citations (Scopus)
8 Downloads (Pure)

Abstract

The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.

Original languageEnglish
Article number355
Number of pages16
JournalMarine Drugs
Volume16
Issue number10
DOIs
Publication statusPublished - 29 Sep 2018

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Oceans and Seas
Anti-Bacterial Agents
Ecosystem
Multiple Drug Resistance
Fermentation
Communicable Diseases
Bacteria
Pharmaceutical Preparations

Keywords

  • antibiotics
  • deep-sea
  • marine microorganisms
  • extreme habitat
  • marine sediments

Cite this

Tortorella, E., Tedesco, P., Palma Esposito, F., January, G. G., Fani, R., Jaspars, M., & de Pascale, D. (2018). Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Marine Drugs, 16(10), [355]. https://doi.org/10.3390/md16100355

Antibiotics from Deep-Sea Microorganisms : Current Discoveries and Perspectives. / Tortorella, Emiliana; Tedesco, Pietro; Palma Esposito, Fortunato; January, Grant Garren; Fani, Renato; Jaspars, Marcel; de Pascale, Donatella (Corresponding Author).

In: Marine Drugs, Vol. 16, No. 10, 355, 29.09.2018.

Research output: Contribution to journalReview article

Tortorella, E, Tedesco, P, Palma Esposito, F, January, GG, Fani, R, Jaspars, M & de Pascale, D 2018, 'Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives', Marine Drugs, vol. 16, no. 10, 355. https://doi.org/10.3390/md16100355
Tortorella E, Tedesco P, Palma Esposito F, January GG, Fani R, Jaspars M et al. Antibiotics from Deep-Sea Microorganisms: Current Discoveries and Perspectives. Marine Drugs. 2018 Sep 29;16(10). 355. https://doi.org/10.3390/md16100355
Tortorella, Emiliana ; Tedesco, Pietro ; Palma Esposito, Fortunato ; January, Grant Garren ; Fani, Renato ; Jaspars, Marcel ; de Pascale, Donatella. / Antibiotics from Deep-Sea Microorganisms : Current Discoveries and Perspectives. In: Marine Drugs. 2018 ; Vol. 16, No. 10.
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