Abstract
The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.
| Original language | English |
|---|---|
| Article number | 355 |
| Number of pages | 16 |
| Journal | Marine Drugs |
| Volume | 16 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 29 Sep 2018 |
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Keywords
- antibiotics
- deep-sea
- marine microorganisms
- extreme habitat
- marine sediments
Cite this
Antibiotics from Deep-Sea Microorganisms : Current Discoveries and Perspectives. / Tortorella, Emiliana; Tedesco, Pietro; Palma Esposito, Fortunato; January, Grant Garren; Fani, Renato; Jaspars, Marcel; de Pascale, Donatella (Corresponding Author).
In: Marine Drugs, Vol. 16, No. 10, 355, 29.09.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Antibiotics from Deep-Sea Microorganisms
T2 - Current Discoveries and Perspectives
AU - Tortorella, Emiliana
AU - Tedesco, Pietro
AU - Palma Esposito, Fortunato
AU - January, Grant Garren
AU - Fani, Renato
AU - Jaspars, Marcel
AU - de Pascale, Donatella
N1 - Funding: This research was funded by the MarPipe project: Improving the flow in the pipeline of the next generation of marine biodiscovery scientists, funded through the European Commission H2020-MSCA-ITN-ETN scheme, GA721421.
PY - 2018/9/29
Y1 - 2018/9/29
N2 - The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.
AB - The increasing emergence of new forms of multidrug resistance among human pathogenic bacteria, coupled with the consequent increase of infectious diseases, urgently requires the discovery and development of novel antimicrobial drugs with new modes of action. Most of the antibiotics currently available on the market were obtained from terrestrial organisms or derived semisynthetically from fermentation products. The isolation of microorganisms from previously unexplored habitats may lead to the discovery of lead structures with antibiotic activity. The deep-sea environment is a unique habitat, and deep-sea microorganisms, because of their adaptation to this extreme environment, have the potential to produce novel secondary metabolites with potent biological activities. This review covers novel antibiotics isolated from deep-sea microorganisms. The chemical classes of the compounds, their bioactivities, and the sources of organisms are outlined. Furthermore, the authors report recent advances in techniques and strategies for the exploitation of deep-sea microorganisms.
KW - antibiotics
KW - deep-sea
KW - marine microorganisms
KW - extreme habitat
KW - marine sediments
U2 - 10.3390/md16100355
DO - 10.3390/md16100355
M3 - Review article
C2 - 30274274
VL - 16
JO - Marine Drugs
JF - Marine Drugs
SN - 1660-3397
IS - 10
M1 - 355
ER -