Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia.

Martin Taylor-Rowan, Olga Kraia, Christina Kolliopoulou, Amanda J. Cross, Carrie Stewart, Phyo Kyaw Myint, Jenny McCleery, Terry J Quinn* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Abstract

Objectives
This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:

Primary objective

To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for further cognitive decline or neuropsychiatric disturbances in people with mild cognitive impairment (MCI) or dementia.

Secondary objective
To compare the prognostic validity of different anticholinergic burden scales.

To examine the effect of type of dementia and severity of dementia on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.

To examine the effect of setting (care home versus non‐care home) on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances.

To examine whether anticholinergic burden is a prognostic factor for other clinical outcomes in people with MCI or dementia
Original languageEnglish
Article numberCD015196
Number of pages19
JournalCochrane Database of Systematic Reviews
Volume2021
Issue number11
Early online date24 Jun 2022
DOIs
Publication statusPublished - 22 Aug 2022

Bibliographical note

Acknowledgements
We would like to thank Dr Kate Wang, Dr Andrew Stafford, Ms Catherine Hofstetter, and Dr Joanna Damen for their helpful peer review comments on this protocol.

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