Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with and without prior cognitive impairment

Martin Taylor-Rowan* (Corresponding Author), Ahmed A Alharthi, Anna H Noel-Storr, Phyo K Myint, Carrie Stewart, Jenny McCleery, Terry J Quinn

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

ObjectivesThis is a protocol for a Cochrane Review (intervention). The objectives are as follows:Primary objective• To assess the efficacy and safety of anticholinergic medication reduction interventions to improve cognitive outcomes in bothcognitively healthy older adults and older adults with pre-existing cognitive issues.Secondary objectives• To compare the effectiveness of different types of reduction interventions (e.g. pharmacist-led versus GP-led; educational versus audit and feedback) in reducing overall anticholinergic burden.• To establish optimal duration of anticholinergic reduction interventions; sustainability, and lessons learned for upscaling• To compare results according to differing anticholinergic scales used in medication reduction intervention trials.• To assess the efficacy of anticholinergic medication reduction interventions to improve other clinical outcomes, including mortality, quality of life, clinical global impression, physical function, institutionalisation, falls, cardiovascular diseases, and neurobehavioral outcomes in people with pre-existing cognitive impairment. Anticholinergic deprescribing interventions for reducing risk of cognitive decline or dementia in older adults with and without prior cognitive impairment
Original languageEnglish
Article number: CD015405
Number of pages18
JournalCochrane Database of Systematic Reviews
Volume2022
Issue number12
DOIs
Publication statusPublished - 8 Dec 2022

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