TY - JOUR
T1 - Antifungal and antibacterial activity of 3-alkylpyridinium polymeric analogs of marine toxins
AU - Zovko, Ana
AU - Gabric, Maja Vaukner
AU - Sepcic, Kristina
AU - Pohleven, Franc
AU - Jaklic, Domen
AU - Gunde-Cimerman, Nina
AU - Lu, Zhibao
AU - Edrada-Ebel, RuAngelie
AU - Houssen, Wael E
AU - Mancini, Ines
AU - Defant, Andrea
AU - Jaspars, Marcel
AU - Turk, Tom
PY - 2012/3
Y1 - 2012/3
N2 - Analogs of marine sponge-derived 3-alkylpyridinium compounds (3-APS) were synthesized and screened for possible antibacterial and antifungal activities. They were found to exhibit moderate antibacterial activity. Antifungal potential was tested on pathogenic fungus Candida albicans, baker's yeast Saccharomyces cerevisiae and hypersaline species Wallemia sebi. S. cerevisiae was the most susceptible to the action of selected 3-APS. Inhibitory effects on fungal growth were also studied on two wood-rotting fungi, brown-rot fungus Gloeophyllum trabeum and a white-rot fungus Trametes versicolor. The former showed a higher susceptibility to the action of 3-APS. The highest antifungal potential was observed with the poly-1,3-dodecyl pyridinium chloride (APS12-3, 7), while a complete loss of activity was noticed with the poly-1,3-butyl pyridinium chloride (APS3, 1), suggesting that this activity may closely correlate to the length of their alkyl chains. Based on our results, synthetic APS12-3 is a good candidate to be used as biocide or wood preservative against wood-rotting fungi. (C) 2012 Elsevier Ltd. All rights reserved.
AB - Analogs of marine sponge-derived 3-alkylpyridinium compounds (3-APS) were synthesized and screened for possible antibacterial and antifungal activities. They were found to exhibit moderate antibacterial activity. Antifungal potential was tested on pathogenic fungus Candida albicans, baker's yeast Saccharomyces cerevisiae and hypersaline species Wallemia sebi. S. cerevisiae was the most susceptible to the action of selected 3-APS. Inhibitory effects on fungal growth were also studied on two wood-rotting fungi, brown-rot fungus Gloeophyllum trabeum and a white-rot fungus Trametes versicolor. The former showed a higher susceptibility to the action of 3-APS. The highest antifungal potential was observed with the poly-1,3-dodecyl pyridinium chloride (APS12-3, 7), while a complete loss of activity was noticed with the poly-1,3-butyl pyridinium chloride (APS3, 1), suggesting that this activity may closely correlate to the length of their alkyl chains. Based on our results, synthetic APS12-3 is a good candidate to be used as biocide or wood preservative against wood-rotting fungi. (C) 2012 Elsevier Ltd. All rights reserved.
KW - synthetic analogs
KW - alkylpyridinium compounds
KW - microwave-assisted polymerization
KW - antifungal activity
KW - antibacterial activity
KW - wood-decay fungi
U2 - 10.1016/j.ibiod.2011.10.014
DO - 10.1016/j.ibiod.2011.10.014
M3 - Article
VL - 68
SP - 71
EP - 77
JO - International Biodeterioration & Biodegradation
JF - International Biodeterioration & Biodegradation
SN - 0964-8305
ER -
