Antifungal innate immunity: a perspective from last 10 years

Fabian Salazar, Gordon D. Brown

Research output: Contribution to journalReview article

18 Citations (Scopus)
7 Downloads (Pure)

Abstract

Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.
Original languageEnglish
Pages (from-to)373-397
Number of pages24
JournalJournal of Innate Immunity
Volume10
Early online date16 May 2018
DOIs
Publication statusPublished - 2018

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