Antifungal innate immunity: a perspective from last 10 years

Fabian Salazar; Gordon D. Brown

doi:10.1159/000488539

Antifungal innate immunity: a perspective from last 10 years

Fabian Salazar, Gordon D. Brown

Research output: Contribution to journal › Review article

18 Citations (Scopus)

7 Downloads (Pure)

Abstract

Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.

Original language	English
Pages (from-to)	373-397
Number of pages	24
Journal	Journal of Innate Immunity
Volume	10
Early online date	16 May 2018
DOIs	https://doi.org/10.1159/000488539
Publication status	Published - 2018

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10.1159/000488539Licence: CC BY-NC-ND

Antifungal Innate Immunity
This article is licensed under the Creative Commons AttributionNonCommercial-NoDerivatives 4.0 International License (CC BYNC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.
Final published version, 768 KBLicence: CC BY-NC-ND

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Salazar, F., & Brown, G. D. (2018). Antifungal innate immunity: a perspective from last 10 years. Journal of Innate Immunity, 10, 373-397. https://doi.org/10.1159/000488539

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title = "Antifungal innate immunity: a perspective from last 10 years",

abstract = "Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.",

author = "Fabian Salazar and Brown, {Gordon D.}",

note = "Acknowledgements We apologize to our many colleagues whose valuable contributions we were not able to cite due to space constrains. Conflict of interest Funding was provided by the Wellcome Trust (102705, 097377) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). F. Salazar holds a postdoctoral fellowship from the National Commission for Scientific and Technological Research (CONICYT), Chile. There are not additional conflict of interest to declare.",

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N1 - Acknowledgements We apologize to our many colleagues whose valuable contributions we were not able to cite due to space constrains. Conflict of interest Funding was provided by the Wellcome Trust (102705, 097377) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). F. Salazar holds a postdoctoral fellowship from the National Commission for Scientific and Technological Research (CONICYT), Chile. There are not additional conflict of interest to declare.

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AB - Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.

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