Antifungal innate immunity

a perspective from last 10 years

Fabian Salazar, Gordon D. Brown

Research output: Contribution to journalReview article

7 Citations (Scopus)
6 Downloads (Pure)

Abstract

Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.
Original languageEnglish
Pages (from-to)373-397
Number of pages24
JournalJournal of Innate Immunity
Volume10
Early online date16 May 2018
DOIs
Publication statusPublished - 2018

Fingerprint

Innate Immunity
Fungal Drug Resistance
Opportunistic Infections
Immunity
Fungi
Incidence
Infection
Research
Invasive Fungal Infections

Cite this

Antifungal innate immunity : a perspective from last 10 years. / Salazar, Fabian; Brown, Gordon D.

In: Journal of Innate Immunity, Vol. 10, 2018, p. 373-397.

Research output: Contribution to journalReview article

@article{bffcc76f8fd349a8af9cda97c3795884,
title = "Antifungal innate immunity: a perspective from last 10 years",
abstract = "Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.",
author = "Fabian Salazar and Brown, {Gordon D.}",
note = "Acknowledgements We apologize to our many colleagues whose valuable contributions we were not able to cite due to space constrains. Conflict of interest Funding was provided by the Wellcome Trust (102705, 097377) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). F. Salazar holds a postdoctoral fellowship from the National Commission for Scientific and Technological Research (CONICYT), Chile. There are not additional conflict of interest to declare.",
year = "2018",
doi = "10.1159/000488539",
language = "English",
volume = "10",
pages = "373--397",
journal = "Journal of Innate Immunity",
issn = "1662-811X",
publisher = "S. Karger AG",

}

TY - JOUR

T1 - Antifungal innate immunity

T2 - a perspective from last 10 years

AU - Salazar, Fabian

AU - Brown, Gordon D.

N1 - Acknowledgements We apologize to our many colleagues whose valuable contributions we were not able to cite due to space constrains. Conflict of interest Funding was provided by the Wellcome Trust (102705, 097377) and the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1). F. Salazar holds a postdoctoral fellowship from the National Commission for Scientific and Technological Research (CONICYT), Chile. There are not additional conflict of interest to declare.

PY - 2018

Y1 - 2018

N2 - Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.

AB - Fungal pathogens can rarely cause disease in immunocompetent individuals. However, commensal and normally non-pathogenic environmental fungi can cause life threatening infections in immunocompromised individuals. Over the last few decades, there has been a huge increase in the incidence of invasive opportunistic fungal infections along with a worrying increase in antifungal drug resistance. As a consequence, research focused on understanding the molecular and cellular basis of antifungal immunity has expanded tremendously in the last few years. This review will provide an overview of the most exciting recent advances in innate antifungal immunity, discoveries that are helping to pave the way for the development of new strategies that are desperately needed to combat these devastating diseases.

U2 - 10.1159/000488539

DO - 10.1159/000488539

M3 - Review article

VL - 10

SP - 373

EP - 397

JO - Journal of Innate Immunity

JF - Journal of Innate Immunity

SN - 1662-811X

ER -