TY - JOUR
T1 - Antigen-induced release of macrophage activating factor from rainbow trout Oncorhynchus mykiss leucocytes
AU - Marsden, Matthew J.
AU - Cox, David
AU - Secombes, Christopher J.
PY - 1994/8
Y1 - 1994/8
N2 - The production of macrophage-activating factor (MAF) by rainbow trout, Oncorhynchus mykiss, head kidney leucocytes at varying times post-immunisation, with the fish bacterial pathogen, Aeromonas salmonicida, was investigated and correlated with head kidney lymphocyte proliferation and serum antibody production. MAF production was preceded by lymphocyte proliferation and both responses were highest using whole bacterial cells as the in vitro stimulant. MAF production and antibody production increased 2-3 weeks post-immunisation, and peaked 4-5 weeks post-immunisation. The relative importance of MAF activated phagocytes in the immunological armoury of disease-resistant, vaccinated fish requires further investigation.
AB - The production of macrophage-activating factor (MAF) by rainbow trout, Oncorhynchus mykiss, head kidney leucocytes at varying times post-immunisation, with the fish bacterial pathogen, Aeromonas salmonicida, was investigated and correlated with head kidney lymphocyte proliferation and serum antibody production. MAF production was preceded by lymphocyte proliferation and both responses were highest using whole bacterial cells as the in vitro stimulant. MAF production and antibody production increased 2-3 weeks post-immunisation, and peaked 4-5 weeks post-immunisation. The relative importance of MAF activated phagocytes in the immunological armoury of disease-resistant, vaccinated fish requires further investigation.
UR - http://www.scopus.com/inward/record.url?scp=0027968328&partnerID=8YFLogxK
U2 - 10.1016/0165-2427(94)90008-6
DO - 10.1016/0165-2427(94)90008-6
M3 - Article
C2 - 7975191
AN - SCOPUS:0027968328
VL - 42
SP - 199
EP - 208
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
SN - 0165-2427
IS - 2
ER -
