Antihistamines (H1 receptor antagonists)

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses antihistamines that are used in combination with a nasal decongestant or with a leukotriene receptor antagonist. One randomized, double-blind, placebo-controlled crossover clinical study in patients with persistent allergic rhinitis showed that montelukast combined with either desloratadine or levocetirizine is more effective in reducing symptoms than monotherapy with these agents. All the treatments were well tolerated. Second-generation antihistamines may also be beneficial in patients with asthma and concomitant rhinitis. Drug-induced movement disorders are most commonly associated with neuroleptic drugs. However, there are a few reports of abnormal involuntary movements associated with antihistamines. A pharmacokinetic study in six healthy men after a single dose of cetirizine 20 mg, pilsicainide 50 mg, or both showed that the renal clearance of each was significantly reduced by co-administration. In vitro studies using Xenopus oocytes with microinjected human organic cation transporter 2 and renal cells transfected with human multidrug resistance protein 1 showed that the transport of the substrates of these transporters was inhibited by both cetirizine and pilsicainide.
Original languageEnglish
Title of host publicationSide Effects of Drugs Annual
EditorsJK Aronson
PublisherElsevier Science
Pages297-303
Number of pages7
Volume31
ISBN (Print)978-0-444-53294-7
DOIs
Publication statusPublished - 2009

Fingerprint

Cetirizine
Histamine H1 Receptors
montelukast
Histamine Antagonists
Dyskinesias
Non-Sedating Histamine H1 Antagonists
Nasal Decongestants
Leukotriene Antagonists
Kidney
Movement Disorders
P-Glycoprotein
Rhinitis
Xenopus
Cross-Over Studies
Antipsychotic Agents
Oocytes
Cations
Asthma
Pharmacokinetics
Placebos

Cite this

Walsh, G. M. (2009). Antihistamines (H1 receptor antagonists). In JK. Aronson (Ed.), Side Effects of Drugs Annual (Vol. 31, pp. 297-303). Elsevier Science . https://doi.org/10.1016/S0378-6080(09)03115-8

Antihistamines (H1 receptor antagonists). / Walsh, Garry M.

Side Effects of Drugs Annual . ed. / JK Aronson. Vol. 31 Elsevier Science , 2009. p. 297-303.

Research output: Chapter in Book/Report/Conference proceedingChapter

Walsh, GM 2009, Antihistamines (H1 receptor antagonists). in JK Aronson (ed.), Side Effects of Drugs Annual . vol. 31, Elsevier Science , pp. 297-303. https://doi.org/10.1016/S0378-6080(09)03115-8
Walsh GM. Antihistamines (H1 receptor antagonists). In Aronson JK, editor, Side Effects of Drugs Annual . Vol. 31. Elsevier Science . 2009. p. 297-303 https://doi.org/10.1016/S0378-6080(09)03115-8
Walsh, Garry M. / Antihistamines (H1 receptor antagonists). Side Effects of Drugs Annual . editor / JK Aronson. Vol. 31 Elsevier Science , 2009. pp. 297-303
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