Antimicrobial resistance of Acinetobacter spp. in Europe. (ARPAC Steering Group)

M. van Looveren, H. Goossens, Julie Bruce, ARPAC Steering Group

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Bacteria of the genus Acinetobacter are ubiquitous in nature. These organisms were invariably susceptible to many antibiotics in the 1970s. Since that time, acinetobacters have emerged as multiresistant opportunistic nosocomial pathogens. The taxonomy of the genus Acinetobacter underwent extensive revision in the mid-1980s, and at least 32 named and unnamed species have now been described. Of these, Acinetobacter baumannii and the closely related unnamed genomic species 3 and 13 sensu Tjernberg and Ursing (13TU) are the most relevant clinically. Multiresistant strains of these species causing bacteraemia, pneumonia, meningitis, urinary tract infections and surgical wound infections have been isolated from hospitalised patients worldwide. This review provides an overview of the antimicrobial susceptibilities of Acinetobacter spp. in Europe, as well as the main mechanisms of antimicrobial resistance, and summarises the remaining treatment options for multiresistant Acinetobacter infections.

Original languageEnglish
Pages (from-to)684-704
Number of pages20
JournalClinical Microbiology and Infection
Volume10
Issue number8
DOIs
Publication statusPublished - 2004

Keywords

  • Acinetobacter
  • antimicrobial resistance
  • carbapenems
  • Europe
  • review
  • surveillance
  • INTENSIVE-CARE UNITS
  • IN-VITRO ACTIVITY
  • GRAM-NEGATIVE BACTERIA
  • METALLO-BETA-LACTAMASE
  • AMINOGLYCOSIDE-MODIFYING ENZYMES
  • CALCOACETICUS BIOTYPE ANITRATUS
  • HUMAN CLINICAL SPECIMENS
  • ANTIBIOTIC-RESISTANCE
  • EXTENDED-SPECTRUM
  • CARBAPENEM RESISTANCE

Cite this

Antimicrobial resistance of Acinetobacter spp. in Europe. (ARPAC Steering Group). / van Looveren, M.; Goossens, H.; Bruce, Julie; ARPAC Steering Group.

In: Clinical Microbiology and Infection, Vol. 10, No. 8, 2004, p. 684-704.

Research output: Contribution to journalArticle

van Looveren, M. ; Goossens, H. ; Bruce, Julie ; ARPAC Steering Group. / Antimicrobial resistance of Acinetobacter spp. in Europe. (ARPAC Steering Group). In: Clinical Microbiology and Infection. 2004 ; Vol. 10, No. 8. pp. 684-704.
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