Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins

A PUSZTAI, S.w.b. Ewen, George Grant, David Stanley Brown, J C STEWART, W J PEUMANS, E J M VANDAMME, S BARDOCZ

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Incorporation of N-acetylglucosamine-specific agglutinins from wheat germ (Triticum aestivum; WGA), thorn apple (Datura stramonium) or nettle (Urtica dioica) rhizomes in the diet at the level of 7 g/kg reduced the apparent digestibility and utilization of dietary proteins and the growth of rats, with WGA being the most damaging. As a result of their binding and endocytosis by the epithelial cells of the small intestine, all three lectins were growth factors for the gut and interfered with its metabolism and function to varying degrees. WGA was particularly effective; it induced extensive polyamine-dependent hyperplastic and hypertrophic growth of the small bowel by increasing its content of proteins, RNA and DNA. Furthermore, an appreciable portion of the endocytosed WGA was transported across the gut wall into the systemic circulation, where it was deposited in the walls of the blood and lymphatic vessels. WGA also induced the hypertrophic growth of the pancreas and caused thymus atrophy. Although the transfer of the gene of WGA into crop plants has been advocated to increase their insect resistance, as the presence of this lectin in the diet may harm higher animals at the concentrations required to be effective against most pests, its use in plants as natural insecticide is not without health risks for man.

Original languageEnglish
Pages (from-to)313-321
Number of pages9
JournalBritish Journal of Nutrition
Volume70
Issue number1
Publication statusPublished - Jul 1993

Keywords

  • lectins
  • antinutrients
  • small intestine
  • rat
  • insect resistance
  • plant-lectins
  • cowpea weevil
  • nitrogen

Cite this

PUSZTAI, A., Ewen, S. W. B., Grant, G., Brown, D. S., STEWART, J. C., PEUMANS, W. J., ... BARDOCZ, S. (1993). Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins. British Journal of Nutrition, 70(1), 313-321.

Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins. / PUSZTAI, A ; Ewen, S.w.b.; Grant, George; Brown, David Stanley; STEWART, J C ; PEUMANS, W J ; VANDAMME, E J M ; BARDOCZ, S .

In: British Journal of Nutrition, Vol. 70, No. 1, 07.1993, p. 313-321.

Research output: Contribution to journalArticle

PUSZTAI, A, Ewen, SWB, Grant, G, Brown, DS, STEWART, JC, PEUMANS, WJ, VANDAMME, EJM & BARDOCZ, S 1993, 'Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins', British Journal of Nutrition, vol. 70, no. 1, pp. 313-321.
PUSZTAI A, Ewen SWB, Grant G, Brown DS, STEWART JC, PEUMANS WJ et al. Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins. British Journal of Nutrition. 1993 Jul;70(1):313-321.
PUSZTAI, A ; Ewen, S.w.b. ; Grant, George ; Brown, David Stanley ; STEWART, J C ; PEUMANS, W J ; VANDAMME, E J M ; BARDOCZ, S . / Antinutritive effects of wheat-germ agglutinin and other N-acetylglucosamine-specific lectins. In: British Journal of Nutrition. 1993 ; Vol. 70, No. 1. pp. 313-321.
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