Abstract
Reversed-phase preparative HPLC analysis of the methanol extract of the seeds of Ilex aquifolium afforded two antioxidant phenylacetic acid derivatives, 2,4-dihydroxyphenylacetic acid (1) and 2,4-dihydroxyphenylacetic acid methyl ester (2). The structures were determined by spectroscopic methods. In the DPPH assay for antioxidant activity, the IC50 values of 1 and 2 were 1.50 x 10-3 and 2.55 x 10-3 mg mL-1, respectively, compared to 2.88 x 10-5 mg mL-1 of quercetin, a natural antioxidant.
Original language | English |
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Pages (from-to) | 187-193 |
Number of pages | 7 |
Journal | Acta Pharmaceutica |
Volume | 55 |
Issue number | 2 |
Publication status | Published - Jun 2005 |
Keywords
- Ilex aquifolium (Aquifoliaceae)
- phenylacetic acid derivatives
- antioxidant
- DPPH