Antiphospholipid antibodies and thrombosis

M Greaves

Research output: Contribution to journalArticle

277 Citations (Scopus)

Abstract

Antiphospholipid antibodies are associated with arterial and venous thrombosis, recurrent pregnancy loss, and thrombocytopenia. Although the antibodies have not been conclusively shown to be causal in thrombosis and miscarriage, they are useful laboratory markers for the antiphospholipid syndrome. The identification of the syndrome is clinically important because of the risk of recurrent thrombosis and the need for antithrombotic therapy in many cases. Diagnosis and treatment of antiphospholipid syndrome is difficult, however, because of the protean clinical manifestations and associations, limitations of existing laboratory tests for antiphospholipid antibodies, and the absence of evidence-based guidance on best management.

Original languageEnglish
Pages (from-to)1348-1353
Number of pages6
JournalThe Lancet
Volume353
Publication statusPublished - 1999

Keywords

  • SYSTEMIC LUPUS-ERYTHEMATOSUS
  • ANTIENDOTHELIAL CELL ANTIBODIES
  • ACTIVATED PROTEIN-C
  • ANTICARDIOLIPIN ANTIBODIES
  • VENOUS THROMBOEMBOLISM
  • ANTICOAGULANT-THERAPY
  • PRONE PATIENTS
  • FETAL LOSS
  • BETA-2-GLYCOPROTEIN-I
  • AUTOANTIBODIES

Cite this

Greaves, M. (1999). Antiphospholipid antibodies and thrombosis. The Lancet, 353, 1348-1353.