Antiphospholipid syndrome: State of the art with emphasis on laboratory evaluation

M Greaves

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Antiphospholipid antibodies (aPLs) are associated with arterial and venous thrombosis, recurrent pregnancy loss and thrombocytopenia. Although aPLs have not yet been con elusively shown to be causal in thrombosis and miscarriage, they are useful laboratory markers for the antiphospholipid syndrome (APS). The syndrome can complicate another autoimmune disease, most commonly systemic lupus erythematosus, but more often occurs alone - primary APS. Identification of the syndrome is clinically important because of the risk of recurrent thrombosis and the need for antithrombotic therapy in many cases. Diagnosis and treatment of APS represent significant challenges, however, owing to the protean clinical manifestations and associations, limitations of currently available laboratory tests for aPLs, and the lack of clear evidence-based guidance on optimal management. Copyright (C) 2001 S. Karger AG Basel.

Original languageEnglish
Pages (from-to)16-25
Number of pages10
JournalThrombosis and Haemostasis
Volume30
Publication statusPublished - 2000

Keywords

  • thrombosis
  • laboratory evaluation
  • pregnancy-associated complications
  • antiphospholipid antibody
  • lupus anticoagulant tests
  • anticardiolipin
  • immunoassays
  • SYSTEMIC-LUPUS-ERYTHEMATOSUS
  • PARTIAL THROMBOPLASTIN TIME
  • ANTICARDIOLIPIN ANTIBODIES
  • CLINICAL MANIFESTATIONS
  • RECURRENT MISCARRIAGE
  • PROTEIN-C
  • IN-VITRO
  • THROMBOSIS
  • BETA-2-GLYCOPROTEIN-I
  • ANTICOAGULANTS

Cite this

Antiphospholipid syndrome: State of the art with emphasis on laboratory evaluation. / Greaves, M .

In: Thrombosis and Haemostasis, Vol. 30, 2000, p. 16-25.

Research output: Contribution to journalArticle

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abstract = "Antiphospholipid antibodies (aPLs) are associated with arterial and venous thrombosis, recurrent pregnancy loss and thrombocytopenia. Although aPLs have not yet been con elusively shown to be causal in thrombosis and miscarriage, they are useful laboratory markers for the antiphospholipid syndrome (APS). The syndrome can complicate another autoimmune disease, most commonly systemic lupus erythematosus, but more often occurs alone - primary APS. Identification of the syndrome is clinically important because of the risk of recurrent thrombosis and the need for antithrombotic therapy in many cases. Diagnosis and treatment of APS represent significant challenges, however, owing to the protean clinical manifestations and associations, limitations of currently available laboratory tests for aPLs, and the lack of clear evidence-based guidance on optimal management. Copyright (C) 2001 S. Karger AG Basel.",
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