Antiviral drug discovery: preparing for the next pandemic

Catherine S Adamson, Kelly Chibale, Rebecca J M Goss, Marcel Jaspars, David J Newman, Rosemary A Dorrington

Research output: Contribution to journalArticlepeer-review

Abstract

Clinically approved antiviral drugs are currently available for only 10 of the more than 220 viruses known to infect humans. The SARS-CoV-2 outbreak has exposed the critical need for compounds that can be rapidly mobilised for the treatment of re-emerging or emerging viral diseases, while vaccine development is underway. We review the current status of antiviral therapies focusing on RNA viruses, highlighting strategies for antiviral drug discovery and discuss the challenges, solutions and options to accelerate drug discovery efforts.

Original languageEnglish
Number of pages9
JournalChemical Society Reviews
Early online date1 Feb 2021
DOIs
Publication statusE-pub ahead of print - 1 Feb 2021

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