Antiviral Sensing in Teleost Fish

Jun Zou, Steve Bird, Chris Secombes

Research output: Contribution to journalLiterature review

35 Citations (Scopus)

Abstract

Vertebrates are armed with an array of pattern recognition receptors (PRRs) to sense viral pathogen associated molecular patterns (PAMPs). Upon activation, the PRRs trigger an interferon response which is central to host antiviral defence. Recent studies have demonstrated that the PRR surveillance system is well conserved in vertebrates during evolution. In fact, most classical PRRs characterised in mammals, such as Toll like receptors and the RIG-I-like receptors, have been identified in lower vertebrates. This review summarises recent progress in PRR recognition of viral PAMPs in teleost fish.

Original languageEnglish
Pages (from-to)4185-4193
Number of pages9
JournalCurrent Pharmaceutical Design
Volume16
Issue number38
Publication statusPublished - Dec 2010

Keywords

  • pattern recognition
  • toll like receptors
  • RIG-I like receptor
  • protein kinase R
  • teleost fish
  • double-stranded DNA
  • pattern-recognition receptors
  • trout onchorhynchus-mykiss
  • virulent Edwardsiella-Ictaluri
  • minnowgobicypris-rarus
  • innate immune-response
  • zebrafish danio-rerio
  • UV-inactivated virus
  • carp cyprinus-carpio

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